Sare Gülfem Özlü1, Başak Alan2, Aysegül Şahiner3, Büşra Bulut4, Gülsüm İclal Bayhan5, Sonay İncesoy Özdemir6. 1. MD, Associate Professor, Ankara Yildirim Beyazıt University, Faculty of Medicine, Department of Pediatric Nephrology, Yenimahalle Training and Research Hospital, Yeni Batı Mah., 2026. Caddesi, 2367 Sokak No:4, 06370 Batıkent/Yenimahalle/Ankara, Turkey. 2. MD, General Pediatrics Residency, Ankara Yildirim Beyazıt University, Faculty of Medicine, Department of General Pediatrics, Kızılırmak Mahallesi, 1436.Sokak, Muhsin Yazıcıoğlu Caddesi, Başak Apartmanı, No:2 /26, Çukurambar, Ankara, Turkey. 3. MD, General Pediatrics Specialist, Ankara Yildirim Beyazıt University, Faculty of Medicine, Yenimahalle Training and Research Hospital, Department of General Pediatrics, İnönü Mahallesi, 1794. Sokak, Özmen Park sitesi, No:8 B Blok, Yenimahalle, Ankara, Turkey. 4. MD, General Pediatrics Residency, Ankara Yildirim Beyazıt University, Faculty of Medicine, Department of General Pediatrics, Yenibatı Mahallesi, 2413. Sokak, No:6 Kat:3 Batıkent, Yenimahalle, Ankara, Turkey. 5. MD, Associate Professor, Ankara Yildirim Beyazıt University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Mahmut Esat Bozkurt Caddesi, No: 12/3 Çankaya, Ankara, Turkey. 6. MD, Associate Professor, Ankara Yildirim Beyazıt University, Faculty of Medicine, Department of Pediatric Oncology, Söğütbeli Caddesi, Alya Sitesi, No: 4/10, Etlik, Ankara, Turkey.
Abstract
INTRODUCTION: Parvovirus B19 infection generally presents as a transient viral illness in children but rarely shows systemic lupus erythematosus-like symptoms. CASE REPORT: Here we present a 7-year-old girl with parvovirus B19 infection who had prolonged fever, rash, pancytopenia and hypocomplementemia making it difficult do differentiate from the first episode of systemic lupus erythematosus. Because she had severe progressive pancytopenia she was administered intravenous immune globulin treatment and her clinical course was dramatically improved. DISCUSSION: Parvovirus B19 infection can mimic systemic lupus erythematosus and it may be difficult to differentiate a recent parvovirus B19 infection and the first presentation of systemic lupus erythematosus. Absence of discoid lesions, alopecia, Raynaud phenomenon and autoimmune hemolytic anemia may help to distinguish parvovirus B19 infection from systemic lupus erythematosus. CONCLUSIONS: Parvovirus B19 infection may cause a severe clinical picture resembling systemic lupus erythematosus even in otherwise healthy children. Intravenous immune globulin treatment might be considered in cases resistant to supportive management. GERMS.
INTRODUCTION: Parvovirus B19 infection generally presents as a transient viral illness in children but rarely shows systemic lupus erythematosus-like symptoms. CASE REPORT: Here we present a 7-year-old girl with parvovirus B19 infection who had prolonged fever, rash, pancytopenia and hypocomplementemia making it difficult do differentiate from the first episode of systemic lupus erythematosus. Because she had severe progressive pancytopenia she was administered intravenous immune globulin treatment and her clinical course was dramatically improved. DISCUSSION: Parvovirus B19 infection can mimic systemic lupus erythematosus and it may be difficult to differentiate a recent parvovirus B19 infection and the first presentation of systemic lupus erythematosus. Absence of discoid lesions, alopecia, Raynaud phenomenon and autoimmune hemolytic anemia may help to distinguish parvovirus B19 infection from systemic lupus erythematosus. CONCLUSIONS: Parvovirus B19 infection may cause a severe clinical picture resembling systemic lupus erythematosus even in otherwise healthy children. Intravenous immune globulin treatment might be considered in cases resistant to supportive management. GERMS.
Authors: Jens Modrof; Andreas Berting; Björn Tille; Andreas Klotz; Christina Forstner; Sandra Rieger; Claudia Aberham; Matthias Gessner; Thomas R Kreil Journal: Transfusion Date: 2007-09-27 Impact factor: 3.157