Novita Arbianti1, Septiyani Prihatiningsih2, Dwi Wahyu Indriani3, Dwi Wahyu Indriati4. 1. MD, Clinical Microbiologist, Team of Microbiology Laboratory, Haji General Hospital, Surabaya, 60116, East Java, Indonesia. 2. M.OHS (Occupational Health and Safety), Team of Antimicrobial Resource Alternative Studies for Emerging and Re-emerging Infectious Disease Research Group, Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Dharmawangsa Dalam Selatan no 28-30, Surabaya, 60286, East Java, Indonesia. 3. PhD, Physiologist, Division of System Neurophysiology, National Institute for Physiological Science, Okazaki, 444-8585, Japan. 4. Ph.D, Leader of Antimicrobial Resource Alternative Studies for Emerging and Re-emerging Infectious Disease Research Group, Department of Health, Division of Medical Laboratory Technologist, Faculty of Vocational Studies, Universitas Airlangga, Dharmawangsa Dalam Selatan no 28-30, Surabaya, 60286, East Java, Indonesia.
Abstract
INTRODUCTION: Diabetes mellitus (DM) is a metabolic disease that can cause many complications. The occurrence of urinary tract infection is also considered to be the cause of complications in patients with DM. This study aimed to evaluate the prevalence of urinary tract infection (UTI) and antibiotic-resistant bacteria found in urine culture from patients with DM in Surabaya, Indonesia. METHODS: This study was conducted with a retrospective cross-sectional study design, using a database of 1551 patients with DM admitted to Haji Hospital, Surabaya, Indonesia, from January 2017 to December 2018. Data regarding the bacteria isolated from urine and antimicrobial sensitivity were analyzed. RESULTS: The prevalence of UTI was 3.93% - 61 patients were confirmed with urine culture for UTI diagnosis. The predominant isolates found were Escherichia coli (24.5%) and Enterococcus faecalis (8%). This study also showed multidrug-resistant organisms (MDRO) found in UTI such as Escherichia coli MDRO (3.3 %), Klebsiella pneumoniae MDRO (3.3%), Acinetobacter baumannii MDRO (1.6%), extended-spectrum beta-lactamase (ESBL) Escherichia coli (3.3%). The E. coli were sensitive to fosfomycin (93%), meropenem (93%) and nitrofurantoin (67%). No significant difference in the prevalence of UTI was found among ages, sex, and duration of disease in all patients with DM. CONCLUSIONS: The cases of UTI seen in patients with DM show the importance of monitoring UTI occurrence in this patient category to ensure better treatment for these patients. GERMS.
INTRODUCTION: Diabetes mellitus (DM) is a metabolic disease that can cause many complications. The occurrence of urinary tract infection is also considered to be the cause of complications in patients with DM. This study aimed to evaluate the prevalence of urinary tract infection (UTI) and antibiotic-resistant bacteria found in urine culture from patients with DM in Surabaya, Indonesia. METHODS: This study was conducted with a retrospective cross-sectional study design, using a database of 1551 patients with DM admitted to Haji Hospital, Surabaya, Indonesia, from January 2017 to December 2018. Data regarding the bacteria isolated from urine and antimicrobial sensitivity were analyzed. RESULTS: The prevalence of UTI was 3.93% - 61 patients were confirmed with urine culture for UTI diagnosis. The predominant isolates found were Escherichia coli (24.5%) and Enterococcus faecalis (8%). This study also showed multidrug-resistant organisms (MDRO) found in UTI such as Escherichia coli MDRO (3.3 %), Klebsiella pneumoniae MDRO (3.3%), Acinetobacter baumannii MDRO (1.6%), extended-spectrum beta-lactamase (ESBL) Escherichia coli (3.3%). The E. coli were sensitive to fosfomycin (93%), meropenem (93%) and nitrofurantoin (67%). No significant difference in the prevalence of UTI was found among ages, sex, and duration of disease in all patients with DM. CONCLUSIONS: The cases of UTI seen in patients with DM show the importance of monitoring UTI occurrence in this patient category to ensure better treatment for these patients. GERMS.
Entities:
Keywords:
Diabetes mellitus; Enterococcus faecalis; Escherichia coli; UTI
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