Gala Beykin1, Jeffrey L Goldberg1. 1. Byers Eye Institute at Stanford University, 2452 Watson Ct, Palo Alto, CA 94303.
Abstract
PURPOSE OF REVIEW: This article summarizes the current studies on molecular biomarkers with potential implications in diagnosis, prognosis, and response to treatment in patients with glaucoma. RECENT FINDINGS: Important advances have occurred in the understanding of the pathogenesis of glaucomatous neurodegeneration. Protein biomarkers associated with inflammatory, neurodegenerative, and other molecular pathways have been described in glaucoma patients in tear film, aqueous fluid, vitreous fluid, and serum, however, we are still far from having a clear picture of the whole molecular network that relates to the disease and its implications in clinical use. SUMMARY: Although more studies are needed, current and emerging molecular biomarkers candidates in glaucoma may eventually transition into clinical use and contribute to outline the concept of precision medicine and precision health in glaucoma.
PURPOSE OF REVIEW: This article summarizes the current studies on molecular biomarkers with potential implications in diagnosis, prognosis, and response to treatment in patients with glaucoma. RECENT FINDINGS: Important advances have occurred in the understanding of the pathogenesis of glaucomatous neurodegeneration. Protein biomarkers associated with inflammatory, neurodegenerative, and other molecular pathways have been described in glaucoma patients in tear film, aqueous fluid, vitreous fluid, and serum, however, we are still far from having a clear picture of the whole molecular network that relates to the disease and its implications in clinical use. SUMMARY: Although more studies are needed, current and emerging molecular biomarkers candidates in glaucoma may eventually transition into clinical use and contribute to outline the concept of precision medicine and precision health in glaucoma.
Authors: Meredith S Gregory; Caroline G Hackett; Emma F Abernathy; Karen S Lee; Rebecca R Saff; Andreas M Hohlbaum; Krishna-Sulayman L Moody; Maura W Hobson; Alexander Jones; Paraskevi Kolovou; Saoussen Karray; Andrea Giani; Simon W M John; Dong Feng Chen; Ann Marshak-Rothstein; Bruce R Ksander Journal: PLoS One Date: 2011-03-29 Impact factor: 3.240
Authors: Josianne C Ten Berge; Zainab Fazil; Ingeborgh van den Born; Roger C W Wolfs; Marco W J Schreurs; Wim A Dik; Aniki Rothova Journal: Acta Ophthalmol Date: 2018-10-08 Impact factor: 3.761