| Literature DB >> 33132114 |
Yoshiaki Kitamura1, Mahmoud Kandeel2, Tomoya Kondo3, Akihiro Tanaka3, Yohei Makino3, Noriko Miyamoto4, Aya Shibata3, Masato Ikeda5, Yukio Kitade6.
Abstract
We found that sulfisomidine, a sulfonamide antibiotic, potently binds to the Piwi/Argonaute/Zwille (PAZ) domain of human Argonaute protein 2 and inhibits RNA interference (RNAi). To elucidate the effect on RNAi of strong affinity of the 3'-ends in small interfering RNA (siRNA) to the PAZ domain, chemically modified siRNAs bearing sulfisomidine at the 3'-end were synthesized.Entities:
Keywords: Ago2; PAZ domain; RNAi; Sulfonamide antibiotics; siRNA
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Year: 2020 PMID： 33132114 DOI： 10.1016/j.bmcl.2020.127637
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823