Tugcan Alp Kirkizlar1, Halis Akalin2, Onur Kirkizlar3, Fahir Ozkalemkas4, Vildan Ozkocaman5, Esra Kazak6, Cuneyt Ozakin7, Esra Nur Bulbul8, Ezgi Sezen Ozboz9, Rıdvan Ali10. 1. Uludag University Medical Faculty, Department of Haematology, 16059, Gorukle, Bursa, Turkey. Electronic address: tugcanalp82@hotmail.com. 2. Uludag University Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, 16059, Gorukle, Bursa, Turkey. Electronic address: halis@uludag.edu.tr. 3. Trakya University Medical Faculty, Department of Haematology, 22030, Edirne, Turkey. Electronic address: onurkirkizlar@gmail.com. 4. Uludag University Medical Faculty, Department of Haematology, 16059, Gorukle, Bursa, Turkey. Electronic address: fahir@uludag.edu.tr. 5. Uludag University Medical Faculty, Department of Haematology, 16059, Gorukle, Bursa, Turkey. Electronic address: vildanoz@uludag.edu.tr. 6. Uludag University Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, 16059, Gorukle, Bursa, Turkey. Electronic address: eskazak@uludag.edu.tr. 7. Uludag University Medical Faculty, Department of Clinical Microbiology, 16059, Gorukle, Bursa, Turkey. Electronic address: ozakin@uludag.edu.tr. 8. Uludag University Medical Faculty, Department of Internal Medicine, 16059, Gorukle, Bursa, Turkey. Electronic address: bulbul_en@hotmail.com. 9. Uludag University Medical Faculty, Department of Internal Medicine, 16059, Gorukle, Bursa, Turkey. Electronic address: ezgisezendanaci@gmail.com. 10. Uludag University Medical Faculty, Department of Haematology, 16059, Gorukle, Bursa, Turkey. Electronic address: ridvanali@uludag.edu.tr.
Abstract
BACKGROUND: Vancomycin-resistant enterococcus (VRE) is an infectious agent that can increase morbidity and mortality, especially in patients with neutropenia in haematology departments. We analysed VRE infections and mortality rates among VRE colonized patients with acute leukaemia, defined predisposing risk factors for infection and mortality, and investigated the influence of daptomycin or linezolid treatment on mortality. PATIENTS- METHODS: We included 200 VRE colonized adult acute leukaemia patients with febrile neutropenia between January 2010 and January 2016. Data were collected from electronic files. RESULTS: There were 179 patients in the colonized group, and 21 patients in the infected group. Enterococcus faecium (van A) was isolated from all patients. The infection rate was 10.5 %, and the types of infections noted were as follows: bloodstream (n = 14; 66.7 %), skin and soft tissue (n = 3; 14.3 %), urinary (n = 2; 9.5 %), and others (9.5 %). In the multivariate logistic regression analysis, exposure to invasive procedures, coinfection status, and >15 days of VRE positivity were independent risk factors for VRE infections. In hospital mortality rates were 57.1 % in the infected group, and 9.5 % in the colonized group (p < 0.001). Older age, female gender, absolute neutropenia, and coinfection status were statistically significant predictor of survival. CONCLUSION: Vancomycin-resistant enterococcus infections are associated with high morbidity and mortality in haematology patients with neutropenia. Clinicians should be aware of predisposing risk factors for VRE infection to avoid unfavourable outcomes. We believe that larger studies are necessary regarding the influence of treatment with daptomycin and linezolid.
BACKGROUND:Vancomycin-resistant enterococcus (VRE) is an infectious agent that can increase morbidity and mortality, especially in patients with neutropenia in haematology departments. We analysed VRE infections and mortality rates among VRE colonized patients with acute leukaemia, defined predisposing risk factors for infection and mortality, and investigated the influence of daptomycin or linezolid treatment on mortality. PATIENTS- METHODS: We included 200 VRE colonized adult acute leukaemiapatients with febrile neutropenia between January 2010 and January 2016. Data were collected from electronic files. RESULTS: There were 179 patients in the colonized group, and 21 patients in the infected group. Enterococcus faecium (van A) was isolated from all patients. The infection rate was 10.5 %, and the types of infections noted were as follows: bloodstream (n = 14; 66.7 %), skin and soft tissue (n = 3; 14.3 %), urinary (n = 2; 9.5 %), and others (9.5 %). In the multivariate logistic regression analysis, exposure to invasive procedures, coinfection status, and >15 days of VRE positivity were independent risk factors for VRE infections. In hospital mortality rates were 57.1 % in the infected group, and 9.5 % in the colonized group (p < 0.001). Older age, female gender, absolute neutropenia, and coinfection status were statistically significant predictor of survival. CONCLUSION:Vancomycin-resistant enterococcusinfections are associated with high morbidity and mortality in haematology patients with neutropenia. Clinicians should be aware of predisposing risk factors for VRE infection to avoid unfavourable outcomes. We believe that larger studies are necessary regarding the influence of treatment with daptomycin and linezolid.
Authors: Pavel V Tkachev; Ivan M Pchelin; Daniil V Azarov; Andrey N Gorshkov; Olga V Shamova; Alexander V Dmitriev; Artemiy E Goncharov Journal: Viruses Date: 2022-04-16 Impact factor: 5.818
Authors: Kristýna Hricová; Magdaléna Röderová; Petr Fryčák; Volodymyr Pauk; Ondřej Kurka; Kristýna Mezerová; Taťána Štosová; Jan Bardoň; David Milde; Pavla Kučová; Milan Kolář Journal: Life (Basel) Date: 2021-12-15