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Literature DB >> 33128946

A modular template for the design of thiol-triggered sensors and prodrugs.

Jessica Renee Knight¹, Yingying Wang¹, Shi Xu², Wei Chen¹, Clifford E Berkman¹, Ming Xian³.

Abstract

A unique reaction between thiols (RSH) and alkyl sulfonylbenzothiazole was discovered. This reaction was specific for thiols and produced a sulfinic acid (RSO2H) as the intermediate, which further triggered an intramolecular cyclization to release a -OH containing payload. This reaction was used to develop thiol-triggered fluorescent sensors and prodrugs. The modular design of this template provides tunability of the release profiles of the payloads.

Entities: Chemical

Keywords: Biothiols; Fluorescent probe; Prodrug; Sulfinic acid

Mesh：

Substances：

Year: 2020 PMID： 33128946 PMCID： PMC7736145 DOI： 10.1016/j.saa.2020.119072

Source DB: PubMed Journal: Spectrochim Acta A Mol Biomol Spectrosc ISSN： 1386-1425 Impact factor: 4.098

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References

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A modular template for the design of thiol-triggered sensors and prodrugs.

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