Vahid Ravaghi1, Colum Durkan2, Kate Jones3, Rebecca Girdler4, John Mair-Jenkins5, Gill Davies6, David Wilcox7, Mark Dermont8, Sandra White9, Yvonne Dailey10, Alexander John Morris11. 1. School of Dentistry, 5 Mill Pool Way, Birmingham, B5 7EG, UK. Electronic address: v.ravaghi@bham.ac.uk. 2. Public Health England, 5 St Phillip's Place, Birmingham, B3 2PW, UK. Electronic address: colum.durkan@phe.gov.uk. 3. Public Health England, Wellington House, London, SE1 8UG, UK. Electronic address: kate.jones@phe.gov.uk. 4. Public Health England, Chilton, Didcot OXON, OX11 0RQ, UK. Electronic address: rebecca.girdler@phe.gov.uk. 5. Public Health England East Midlands, City Link, Nottingham, NG2 4LA, UK. Electronic address: john.mairjenkins@phe.gov.uk. 6. Public Health England, Wellington House, London, SE1 8UG, UK. Electronic address: Satveer.kour@phe.gov.uk. 7. Public Health England, Wellington House, London, SE1 8UG, UK. Electronic address: david.wilcox@phe.gov.uk. 8. Joint Medical Group, Coltman House, DMS Whittington, Lichfield, WS14 9PY, UK. Electronic address: mark.dermont240@mod.gov.uk. 9. Public Health England, Wellington House, London, SE1 8UG, UK. Electronic address: sandra.white@phe.gov.uk. 10. Public Health England, Wellington House, London, SE1 8UG, UK. Electronic address: yvonne.dailey@phe.gov.uk. 11. School of Dentistry, 5 Mill Pool Way, Birmingham, B5 7EG, UK. Electronic address: a.j.morris@bham.ac.uk.
Abstract
BACKGROUND: The relationship between deprivation and oral cancer is complex. We examined magnitude and shape of deprivation-related inequalities in oral cancer in England 2012-2016. METHODS: Oral cancer was indicated by cancers of the lip and oral cavity (ICD10 C00-C06) and lip, oral cavity and pharynx (C00-C14) and deprivation by the Index of Multiple Deprivation. Deprivation inequality in incidence and mortality rates of oral cancer outcomes was measured using the Relative Index of Inequality (RII). Fractional polynomial regression was used to explore the shape of the relationships between deprivation and oral cancer outcomes. Multivariate regression models were fitted with the appropriate functions to examine the independent effect of deprivation on cancer adjusting for smoking, alcohol and ethnicity. RESULTS: Incidence rate ratios (IRRs) and mortality rate ratios (MRRs) were greater for more deprived areas. The RII values indicated significant inequalities for oral cancer outcomes but the magnitude of inequalities were greater for mortality. The relationships between deprivation and oral cancer outcomes were curvilinear. Deprivation, Asian ethnicity and alcohol consumption were associated with higher incidence and mortality rates of oral cancer. CONCLUSION: This is the first study, to our knowledge, exploring the shape of socioeconomic inequalities in oral cancer at neighbourhood level. Deprivation-related inequalities were present for all oral cancer outcomes with a steeper rise at the more deprived end of the deprivation spectrum. Deprivation predicted oral cancer even after accounting for other risk factors.
BACKGROUND: The relationship between deprivation and oral cancer is complex. We examined magnitude and shape of deprivation-related inequalities in oral cancer in England 2012-2016. METHODS: Oral cancer was indicated by cancers of the lip and oral cavity (ICD10 C00-C06) and lip, oral cavity and pharynx (C00-C14) and deprivation by the Index of Multiple Deprivation. Deprivation inequality in incidence and mortality rates of oral cancer outcomes was measured using the Relative Index of Inequality (RII). Fractional polynomial regression was used to explore the shape of the relationships between deprivation and oral cancer outcomes. Multivariate regression models were fitted with the appropriate functions to examine the independent effect of deprivation on cancer adjusting for smoking, alcohol and ethnicity. RESULTS: Incidence rate ratios (IRRs) and mortality rate ratios (MRRs) were greater for more deprived areas. The RII values indicated significant inequalities for oral cancer outcomes but the magnitude of inequalities were greater for mortality. The relationships between deprivation and oral cancer outcomes were curvilinear. Deprivation, Asian ethnicity and alcohol consumption were associated with higher incidence and mortality rates of oral cancer. CONCLUSION: This is the first study, to our knowledge, exploring the shape of socioeconomic inequalities in oral cancer at neighbourhood level. Deprivation-related inequalities were present for all oral cancer outcomes with a steeper rise at the more deprived end of the deprivation spectrum. Deprivation predicted oral cancer even after accounting for other risk factors.
Authors: David Muallah; Jan Matschke; Sophie Muallah; Anna Klimova; Lysann Michaela Kroschwald; Tom Alexander Schröder; Günter Lauer; Dominik Haim Journal: Front Public Health Date: 2022-07-22