Literature DB >> 3312482

Production of murine monoclonal antibodies to the major axial filament polypeptide of Treponema pallidum.

M J Bailey1, A Cockayne, C W Penn.   

Abstract

A suitable immunization protocol for the stimulation of a murine antibody response to the axial filament polypeptides of Treponema pallidum was established. A range of monoclonal antibodies (Mabs) specific for different epitopes of the major axial filament polypeptide (37 kDa) was generated which demonstrated diversity in their ability to react with other treponemal species. Immunogold electron microscopy located the 37 kDa antigen on the surface of the axial filament structure. The early appearance of specific antibody to this polypeptide in infected man and rabbit indicates that such Mabs are potentially useful for the diagnosis of early syphilis.

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Year:  1987        PMID： 3312482     DOI： 10.1099/00221287-133-7-1805

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  8 in total

1.  T-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection.

Authors:  T W Arroll; A Centurion-Lara; S A Lukehart; W C Van Voorhis
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

2.  A new attempt to distinguish serologically the subspecies of Treponema pallidum causing syphilis and yaws.

Authors:  G T Noordhoek; A Cockayne; L M Schouls; R H Meloen; E Stolz; J D van Embden
Journal:  J Clin Microbiol       Date:  1990-07       Impact factor: 5.948

3.  Biochemical and cytological analysis of the complex periplasmic flagella from Spirochaeta aurantia.

Authors:  B Brahamsha; E P Greenberg
Journal:  J Bacteriol       Date:  1988-09       Impact factor: 3.490

4.  Antigenic relatedness and N-terminal sequence homology define two classes of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and Treponema phagedenis.

Authors:  S J Norris; N W Charon; R G Cook; M D Fuentes; R J Limberger
Journal:  J Bacteriol       Date:  1988-09       Impact factor: 3.490

5.  Rapid in vitro immobilisation of purified Treponema pallidum (Nichols strain), and protection by extraction fluids from rabbit testes.

Authors:  H J Engelkens; M Kant; P C Onvlee; E Stolz; J J van der Sluis
Journal:  Genitourin Med       Date:  1990-10

6.  Specific immunofluorescent staining of pathogenic treponemes with a monoclonal antibody.

Authors:  F Ito; E F Hunter; R W George; V Pope; S A Larsen
Journal:  J Clin Microbiol       Date:  1992-04       Impact factor: 5.948

Review 7.  Polypeptides of Treponema pallidum: progress toward understanding their structural, functional, and immunologic roles. Treponema Pallidum Polypeptide Research Group.

Authors:  S J Norris
Journal:  Microbiol Rev       Date:  1993-09

8.  Cloning and sequencing of a Treponema pallidum gene encoding a 31.3-kilodalton endoflagellar subunit (FlaB2).

Authors:  L Pallesen; P Hindersson
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441
  8 in total

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