Na Li1,2, Min Jia1, Qianchun Deng3, Zhen Wang4, Fenghong Huang1, Hanxue Hou5, Tongcheng Xu6. 1. Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences/Shandong Engineering Research Center of Food for Special Medical Purpose/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs, 202 Gongyebei Road, Jinan, 250100, China. 2. Food Science and Engineering of Shandong Agricultural University, Taian, 271000, Shandong, China. 3. Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, China. 4. School of Public Health, Shandong University, Jinan, China. 5. Food Science and Engineering of Shandong Agricultural University, Taian, 271000, Shandong, China. hhx@sdau.edu.cn. 6. Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Sciences/Shandong Engineering Research Center of Food for Special Medical Purpose/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs, 202 Gongyebei Road, Jinan, 250100, China. xtc@live.com.
Abstract
PURPOSE: The aim of this meta-analysis was to evaluate the effects of low-ratio n-6/n-3 PUFA on blood lipid levels. METHODS: We searched the PubMed, Embase, and Cochrane Library databases for randomized controlled trials of n-6/n-3 PUFA interventions up to March 2019. The change values were calculated as weighted mean differences (WMDs) by using a random-effect model. Subgroup analysis and meta-regression were used to explore the source of heterogeneity. RESULTS: A total of 30 randomized controlled trials with 1368 participants were identified. Compared with control, low-ratio n-6/n-3 PUFA significantly reduced triglyceride (TG) concentration (WMD: - 0.079 mmol/L, 95% confidence interval (CI): - 0.148 mmol/L to - 0.009 mmol/L, p = 0.026) and increased high-density lipoprotein cholesterol (HDL-C) concentration (WMD: 0.033 mmol/L, 95% CI: 0.007 to 0.058 mmol/L, p = 0.012). Subgroup analysis revealed that the effects of low-ratio n-6/n-3 PUFA on blood lipid levels were better for a longer time. The effects of α-linolenic acid on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations were more obvious among participants. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) had more significant effects on TG and HDL-C concentrations. No significant publication bias was observed for TG and HDL-C, as suggested by the results of Begg's test and Egger's test. CONCLUSION: Low-ratio n-6/n-3 PUFA significantly reduced TG concentration and increased HDL-C concentration. The beneficial effects of low-ratio n-6/n-3 PUFA on TG, TC, HDL-C, and LDL-C concentrations were enhanced with time. However, n-3 PUFA derived from plants significantly reduced TC and LDL-C concentrations, and n-3 PUFA derived from EPA and DHA significantly reduced TG concentration and increased HDL-C concentration.
PURPOSE: The aim of this meta-analysis was to evaluate the effects of low-ratio n-6/n-3 PUFA on blood lipid levels. METHODS: We searched the PubMed, Embase, and Cochrane Library databases for randomized controlled trials of n-6/n-3 PUFA interventions up to March 2019. The change values were calculated as weighted mean differences (WMDs) by using a random-effect model. Subgroup analysis and meta-regression were used to explore the source of heterogeneity. RESULTS: A total of 30 randomized controlled trials with 1368 participants were identified. Compared with control, low-ratio n-6/n-3 PUFA significantly reduced triglyceride (TG) concentration (WMD: - 0.079 mmol/L, 95% confidence interval (CI): - 0.148 mmol/L to - 0.009 mmol/L, p = 0.026) and increased high-density lipoprotein cholesterol (HDL-C) concentration (WMD: 0.033 mmol/L, 95% CI: 0.007 to 0.058 mmol/L, p = 0.012). Subgroup analysis revealed that the effects of low-ratio n-6/n-3 PUFA on blood lipid levels were better for a longer time. The effects of α-linolenic acid on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations were more obvious among participants. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) had more significant effects on TG and HDL-C concentrations. No significant publication bias was observed for TG and HDL-C, as suggested by the results of Begg's test and Egger's test. CONCLUSION: Low-ratio n-6/n-3 PUFA significantly reduced TG concentration and increased HDL-C concentration. The beneficial effects of low-ratio n-6/n-3 PUFA on TG, TC, HDL-C, and LDL-C concentrations were enhanced with time. However, n-3 PUFA derived from plants significantly reduced TC and LDL-C concentrations, and n-3 PUFA derived from EPA and DHA significantly reduced TG concentration and increased HDL-C concentration.
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