Jaelim Cho1, Robert Scragg2, Maxim S Petrov3. 1. Department of Surgery, University of Auckland, Auckland, New Zealand. 2. School of Population Health, University of Auckland, Auckland, New Zealand. 3. Department of Surgery, University of Auckland, Auckland, New Zealand. Electronic address: max.petrov@gmail.com.
Abstract
BACKGROUND: It is unknown whether cholecystectomy for acute pancreatitis (AP) affects the risk of post-pancreatitis diabetes mellitus (PPDM). We aimed to investigate the associations between cholecystectomy, recurrent biliary events prior to cholecystectomy, and the risk of PPDM in patients with AP. METHODS: Using New Zealand nationwide data from 2007 to 2016, patients with first admission for AP were identified (n = 10,870). Cholecystectomy was considered as a time-dependent exposure. Timing of cholecystectomy was categorized as same-admission, readmission, and delayed cholecystectomy. Recurrent biliary events prior to cholecystectomy were identified. Multivariable Cox regression analyses were conducted. RESULTS: Among 2147 patients who underwent cholecystectomy, 141 (6.6%) developed PPDM. Overall, cholecystectomy was not significantly associated with the risk of PPDM (adjusted hazard ratio, 1.14; 95% confidence interval, 0.94-1.38). Delayed cholecystectomy was significantly associated with an increased risk of PPDM (adjusted hazard ratio, 1.36; 95% confidence interval, 1.01-1.83). Patients who had 2 or ≥3 recurrent biliary events prior to cholecystectomy were at a significantly increased risk of PPDM. CONCLUSION: Cholecystectomy in general was not associated with the risk of PPDM in patients with AP. Two or more repeated attacks of AP (or other biliary events) were associated with a significantly increased risk of PPDM.
BACKGROUND: It is unknown whether cholecystectomy for acute pancreatitis (AP) affects the risk of post-pancreatitis diabetes mellitus (PPDM). We aimed to investigate the associations between cholecystectomy, recurrent biliary events prior to cholecystectomy, and the risk of PPDM in patients with AP. METHODS: Using New Zealand nationwide data from 2007 to 2016, patients with first admission for AP were identified (n = 10,870). Cholecystectomy was considered as a time-dependent exposure. Timing of cholecystectomy was categorized as same-admission, readmission, and delayed cholecystectomy. Recurrent biliary events prior to cholecystectomy were identified. Multivariable Cox regression analyses were conducted. RESULTS: Among 2147 patients who underwent cholecystectomy, 141 (6.6%) developed PPDM. Overall, cholecystectomy was not significantly associated with the risk of PPDM (adjusted hazard ratio, 1.14; 95% confidence interval, 0.94-1.38). Delayed cholecystectomy was significantly associated with an increased risk of PPDM (adjusted hazard ratio, 1.36; 95% confidence interval, 1.01-1.83). Patients who had 2 or ≥3 recurrent biliary events prior to cholecystectomy were at a significantly increased risk of PPDM. CONCLUSION: Cholecystectomy in general was not associated with the risk of PPDM in patients with AP. Two or more repeated attacks of AP (or other biliary events) were associated with a significantly increased risk of PPDM.
Authors: Péter J Hegyi; Alexandra Soós; Emese Tóth; Attila Ébert; Viktória Venglovecz; Katalin Márta; Péter Mátrai; Alexandra Mikó; Judit Bajor; Patrícia Sarlós; Áron Vincze; Adrienn Halász; Ferenc Izbéki; Zoltán Szepes; László Czakó; György Kovács; Mária Papp; Zsolt Dubravcsik; Márta Varga; József Hamvas; Balázs C Németh; Melania Macarie; Ali Tüzün Ince; Dmitry S Bordin; Elena A Dubtsova; Mariya A Kiryukova; Igor E Khatkov; Tanya Bideeva; Artautas Mickevicius; Elena Ramírez-Maldonado; Ville Sallinen; Bálint Erőss; Dániel Pécsi; Andrea Szentesi; Andrea Párniczky; László Tiszlavicz; Péter Hegyi Journal: Sci Rep Date: 2021-01-14 Impact factor: 4.379