Kodai Ishihara1, Kazuhiro P Izawa2, Masahiro Kitamura3, Masato Ogawa4, Takayuki Shimogai5, Yuji Kanejima5, Tomoyuki Morisawa6, Ikki Shimizu7. 1. Department of Rehabilitation, Sakakibara Heart Institute of Okayama, Okayama, Japan; Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe, Japan; Cardiovascular Stroke Renal Project (CRP), Japan. 2. Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe, Japan; Cardiovascular Stroke Renal Project (CRP), Japan. Electronic address: izawapk@harbor.kobe-u.ac.jp. 3. Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe, Japan; Cardiovascular Stroke Renal Project (CRP), Japan; Department of Physical Therapy, Fukuoka Wajiro Professional Training College, Fukuoka, Japan. 4. Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe, Japan; Cardiovascular Stroke Renal Project (CRP), Japan; Department of Rehabilitation Medicine, Kobe University Hospital, Kobe, Japan. 5. Department of Public Health, Graduate School of Health Sciences, Kobe University, Kobe, Japan; Cardiovascular Stroke Renal Project (CRP), Japan; Department of Rehabilitation, Kobe City Medical Center General Hospital, Kobe, Japan. 6. Department of Physical Therapy, Faculty of Health Sciences, Juntendo University, Tokyo, Japan. 7. Department of Diabetes, Sakakibara Heart Institute of Okayama, Okayama, Japan.
Abstract
BACKGROUND: We aimed to examine the relationship between the difficulty of activity using the arms and mild cognitive impairment (MCI), the relationship between the difficulty of activity using the arms and manual function, and cognitive function in patients with coronary artery disease (CAD). METHODS: We conducted a cross-sectional study of 263 non-dementia patients who met the study criteria from 2328 CAD patients. MCI was estimated with the Japanese version of the Montreal Cognitive Assessment (MoCA-J). The difficulty of activity using the arms was evaluated using the Disability of the Arm, Shoulder, Disability of the Arm, Shoulder and Hand and Hand (DASH) questionnaire. Manual function was evaluated by pinch strength and handgrip strength. RESULTS: Age (odds ratio, 1.10), three-fingered pinch strength (odds ratio, 0.69), and DASH score (odds ratio, 1.03) were independently associated with MCI in the multivariable logistic regression analysis. Hemoglobin (β=-0.15), handgrip strength (β=-0.37), and MoCA-J score (β=-0.15) were independently associated with DASH score (Model 1: p<0.001, adjusted R2=0.33); hemoglobin (β=-0.17), eGFR (β=-0.14), three-fingered pinch strength (β=-0.25), and MoCA-J score (β=-0.14) were independently associated with DASH score in the multivariate regression analysis (Model 2: p<0.001, adjusted R2=0.31). CONCLUSIONS: The difficulty of activity using the arms was independently associated with manual and cognitive function and MCI in CAD patients.
BACKGROUND: We aimed to examine the relationship between the difficulty of activity using the arms and mild cognitive impairment (MCI), the relationship between the difficulty of activity using the arms and manual function, and cognitive function in patients with coronary artery disease (CAD). METHODS: We conducted a cross-sectional study of 263 non-dementiapatients who met the study criteria from 2328 CAD patients. MCI was estimated with the Japanese version of the Montreal Cognitive Assessment (MoCA-J). The difficulty of activity using the arms was evaluated using the Disability of the Arm, Shoulder, Disability of the Arm, Shoulder and Hand and Hand (DASH) questionnaire. Manual function was evaluated by pinch strength and handgrip strength. RESULTS: Age (odds ratio, 1.10), three-fingered pinch strength (odds ratio, 0.69), and DASH score (odds ratio, 1.03) were independently associated with MCI in the multivariable logistic regression analysis. Hemoglobin (β=-0.15), handgrip strength (β=-0.37), and MoCA-J score (β=-0.15) were independently associated with DASH score (Model 1: p<0.001, adjusted R2=0.33); hemoglobin (β=-0.17), eGFR (β=-0.14), three-fingered pinch strength (β=-0.25), and MoCA-J score (β=-0.14) were independently associated with DASH score in the multivariate regression analysis (Model 2: p<0.001, adjusted R2=0.31). CONCLUSIONS: The difficulty of activity using the arms was independently associated with manual and cognitive function and MCI in CAD patients.