Acceptance of a COVID-19 vaccine: A multifactorial consideration.

The individual decision process of whether or not to vaccinate against COVID-19 is multifactorial and must be considered in the design of any vaccination campaign. Specifically, the willingness to vaccinate against SARS-CoV-2 depends on: (a) Availability, i.e. the actual existence of an effective vaccine and its country of origin; (b) Access to the vaccine, which could be limited by individual or governmental budgetary restrictions to finance preventive public health measures; (c) Perceived health risk, which depends on the intensity and severity of side effects and COVID-19 prevalence; (d) Information on benefits, risks and access pathways; (e) Previous experience with other vaccines and exposure to diseases, as this affects risk perception; and (f) Sociodemographic factors including age, education level, gender and more.

In fact, the preliminary results of a Chilean case study on COVID-19 vaccine perception in the country, with a nationwide representative sample of 1097 individuals, shows that 87% are willing to vaccinate, a relatively high proportion and slightly lower than the rate found by García and Cerda [1], 90.6% for Chile. It must be said that the Chilean case is unique, as the infection rate per million inhabitants is one of the highest on Earth (20986.05), but the lethality rate is the lowest (572), both of which have opposite effects on vaccination intention.

This illustrates that circumstantial conditions such as the pandemic context, specifically disease prevalence in a particular population can also impact vaccination intention. In fact, Feleszko, Wojciech and Lewulis [2] show that there are important differences between countries in the percentage of individuals who declare a positive intention towards vaccination against COVID-19, which varies between 41% and 89%. These differences could reflect individual preferences, influenced by the plethora of factors mentioned above.

This is why each country must design its own vaccination strategy based on the characteristics of its population and prevalence, considering a holistic vaccination design that effectively considers all the factors that influence vaccination decisions. According to Paakkari [3], Schaffer et al. [4] and Harrison [5], a transparent educational and communicative campaign is needed, one that considers interaction between health policymakers in a way that allows people to value the personal and social benefit of being vaccinated against COVID-19, reducing hesitation.

Therefore, it is necessary for each government to take the public health measures necessary for its culture, its perceptions and the demographic characteristics of its population. The same international applicability framework must also be considered to design the vaccination campaign based on information, education and awareness towards social benefit.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.