OBJECTIVE: To identify early life adversity (ELA) risk factors for earlier pubertal timing, itself a risk factor for poor cardiometabolic health, and to determine whether such ELA-related risk may be mediated by pre-pubertal body mass index (BMI). METHODS: Subjects included 426 female participants in a prospective birth cohort study, the NICHD Study of Early Child Care and Youth Development. Survival analysis models were fit to examine ELA exposures, representing childhood socioeconomic status (SES), maternal sensitivity, mother-child attachment, and negative life events, along with child health indicators and covariates, in relation to pubertal timing outcomes, including age at menarche and ages at Tanner stage II for breast and pubic hair development. RESULTS: Higher childhood SES emerged as an independent predictor of older age at menarche, showing each one standard deviation increase in childhood SES corresponded to a 1.3% increase in age at menarche (factor change = 1.013; 1.003-1.022; p < .01), but did not predict breast or pubic hair development (ps > .05). In mediation analyses, indirect (mediated) effects of mother-child attachment on the pubertal timing outcomes, via pre-pubertal BMI, were all statistically significant (ps < .05). CONCLUSIONS: Higher childhood SES predicted directly, and secure (vs. insecure) mother-child attachment predicted indirectly (via pre-pubertal BMI), later pubertal timing, suggesting these factors may protect girls from earlier pubertal development. By extension, clinical implications are that intervention strategies designed to lessen ELA- and pre-pubertal obesity-related risk may be effective in remediating life course pathways linking ELA, accelerated pubertal development, and cardiometabolic risk.
OBJECTIVE: To identify early life adversity (ELA) risk factors for earlier pubertal timing, itself a risk factor for poor cardiometabolic health, and to determine whether such ELA-related risk may be mediated by pre-pubertal body mass index (BMI). METHODS: Subjects included 426 female participants in a prospective birth cohort study, the NICHD Study of Early Child Care and Youth Development. Survival analysis models were fit to examine ELA exposures, representing childhood socioeconomic status (SES), maternal sensitivity, mother-child attachment, and negative life events, along with child health indicators and covariates, in relation to pubertal timing outcomes, including age at menarche and ages at Tanner stage II for breast and pubic hair development. RESULTS: Higher childhood SES emerged as an independent predictor of older age at menarche, showing each one standard deviation increase in childhood SES corresponded to a 1.3% increase in age at menarche (factor change = 1.013; 1.003-1.022; p < .01), but did not predict breast or pubic hair development (ps > .05). In mediation analyses, indirect (mediated) effects of mother-child attachment on the pubertal timing outcomes, via pre-pubertal BMI, were all statistically significant (ps < .05). CONCLUSIONS: Higher childhood SES predicted directly, and secure (vs. insecure) mother-child attachment predicted indirectly (via pre-pubertal BMI), later pubertal timing, suggesting these factors may protect girls from earlier pubertal development. By extension, clinical implications are that intervention strategies designed to lessen ELA- and pre-pubertal obesity-related risk may be effective in remediating life course pathways linking ELA, accelerated pubertal development, and cardiometabolic risk.
Authors: Karen E Remsberg; Ellen W Demerath; Christine M Schubert; Wm Cameron Chumlea; Shumei S Sun; Roger M Siervogel Journal: J Clin Endocrinol Metab Date: 2005-02-22 Impact factor: 5.958
Authors: Robert A Hiatt; Susan L Stewart; Kristin S Hoeft; Lawrence H Kushi; Gayle C Windham; Frank M Biro; Susan M Pinney; Mary S Wolff; Susan L Teitelbaum; Dejana Braithwaite Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-09-22 Impact factor: 4.254
Authors: Shakira F Suglia; Rebecca A Campo; Alison G M Brown; Catherine Stoney; Cheryl A Boyce; Allison A Appleton; Maria E Bleil; Renée Boynton-Jarrett; Shanta R Dube; Erin C Dunn; Bruce J Ellis; Christopher P Fagundes; Nia J Heard-Garris; Sara R Jaffee; Sara B Johnson; Mahasin S Mujahid; Natalie Slopen; Shaoyong Su; Sarah E Watamura Journal: J Pediatr Date: 2020-02-25 Impact factor: 4.406
Authors: Elissa June Hamlat; Barbara Laraia; Maria E Bleil; Julianna Deardorff; A Janet Tomiyama; Mahasin Mujahid; Grant S Shields; Kristy Brownell; George M Slavich; Elissa S Epel Journal: Psychosom Med Date: 2022-04-01 Impact factor: 3.864