| Literature DB >> 33119554 |
Anita K Kambhampati, Alissa C O'Halloran, Michael Whitaker, Shelley S Magill, Nora Chea, Shua J Chai, Pam Daily Kirley, Rachel K Herlihy, Breanna Kawasaki, James Meek, Kimberly Yousey-Hindes, Evan J Anderson, Kyle P Openo, Maya L Monroe, Patricia A Ryan, Sue Kim, Libby Reeg, Kathryn Como-Sabetti, Richard Danila, Sarah Shrum Davis, Salina Torres, Grant Barney, Nancy L Spina, Nancy M Bennett, Christina B Felsen, Laurie M Billing, Jessica Shiltz, Melissa Sutton, Nicole West, William Schaffner, H Keipp Talbot, Ryan Chatelain, Mary Hill, Lynnette Brammer, Alicia M Fry, Aron J Hall, Jonathan M Wortham, Shikha Garg, Lindsay Kim.
Abstract
Health care personnel (HCP) can be exposed to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), both within and outside the workplace, increasing their risk for infection. Among 6,760 adults hospitalized during March 1-May 31, 2020, for whom HCP status was determined by the COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), 5.9% were HCP. Nursing-related occupations (36.3%) represented the largest proportion of HCP hospitalized with COVID-19. Median age of hospitalized HCP was 49 years, and 89.8% had at least one underlying medical condition, of which obesity was most commonly reported (72.5%). A substantial proportion of HCP with COVID-19 had indicators of severe disease: 27.5% were admitted to an intensive care unit (ICU), 15.8% required invasive mechanical ventilation, and 4.2% died during hospitalization. HCP can have severe COVID-19-associated illness, highlighting the need for continued infection prevention and control in health care settings as well as community mitigation efforts to reduce transmission.Entities:
Mesh:
Year: 2020 PMID: 33119554 PMCID: PMC7659917 DOI: 10.15585/mmwr.mm6943e3
Source DB: PubMed Journal: MMWR Morb Mortal Wkly Rep ISSN: 0149-2195 Impact factor: 17.586
FIGURE 1Selection of cases for analysis of COVID-19–associated hospitalizations among health care personnel (HCP)* — COVID-NET, 13 states, March 1–May 31, 2020
Abbreviations: COVID-19 = coronavirus disease 2019; COVID–NET = COVID–19–Associated Hospitalization Surveillance Network.
* All case counts are unweighted.
† Sites located in the following 13 states: California, Colorado, Connecticut, Georgia, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah.
Demographic and clinical characteristics of health care personnel (HCP) with COVID-19-associated hospitalizations, overall and by type of patient contact* — COVID-NET, 13 states, March 1–May 31, 2020
| Characteristic | Overall (N = 438) | Direct patient contact (N = 293) | No direct patient contact (N = 145) | |||
|---|---|---|---|---|---|---|
| Unweighted no. (weighted %) | 95% CI | Unweighted no. (weighted %) | 95% CI | Unweighted no. (weighted %) | 95% CI | |
|
| ||||||
| Direct patient contact | 293 (67.4) | (59.9–74.1) | — | — | — | — |
| No direct patient contact | 145 (32.6) | (25.9–40.1) | — | — | — | — |
|
| ||||||
| 18 | 278 (46.4) | (39.1–53.7) | 183 (44.4) | (35.7–53.4) | 95 (50.5) | (37.6–63.4) |
| 50 | 139 (46.1) | (38.9–53.5) | 99 (51.0) | (42.0–59.9) | 40 (36.0) | (24.7–49.2) |
| ≥65 yrs | 21 (7.5) | (4.1–13.3) | 11 (4.7) | (2.0–10.7) | 10 (13.4) | (5.9–27.7) |
| Median age in years (IQR) | 49 (38–57) | — | 52 (38–57) | — | 48 (37–57) | — |
|
| ||||||
| White, non-Hispanic | 142 (27.4) | (21.5–34.1) | 104 (33.3) | (25.5–42.2) | 38 (15.0) | (8.9–24.3) |
| Black, non-Hispanic | 184 (52.0) | (44.5–59.5) | 113 (44.7) | (35.6–54.1) | 71 (67.3) | (55.2–77.4) |
| Hispanic or Latino | 48 (8.6) | (5.3–13.8) | 30 (9.8) | (5.3–17.3) | 18 (6.3) | (3.4–11.3) |
| American Indian or Alaska Native, non-Hispanic | 39 (6.8) | (4.2–10.8) | 29 (6.8) | (4.0–11.5) | 10 (6.7) | (2.5–16.9) |
| Asian or Pacific Islander, non-Hispanic | 12 (3.2) | (1.5–6.6) | 10 (4.4) | (2.0–9.6) | 2 (0.6) | (0.1–2.3) |
| Multiple races | 1 (0.1) | (0.0–0.7) | 1 (0.1) | (0.0–1.0) | — | — |
| Unknown | 12 (1.9) | (0.7–4.9) | 6 (0.8) | (0.4–1.9) | 6 (4.1) | (1.1–14.1) |
|
| ||||||
| Male | 131 (28.1) | (21.8–35.3) | 88 (29.5) | (21.8–38.6) | 43 (25.2) | (15.6–37.9) |
| Female | 307 (71.9) | (64.7–78.2) | 205 (70.5) | (61.4–78.2) | 102 (74.8) | (62.1–84.4) |
|
| ||||||
| Any underlying condition§ | 377 (89.8) | (85.0–93.2) | 248 (87.8) | (81.0–92.4) | 129 (94.0) | (88.5–97.0) |
| Obesity (n = 396) | 270 (72.5) | (65.2–78.7) | 177 (68.3) | (58.8–76.4) | 93 (80.9) | (70.3–88.4) |
| Hypertension | 158 (40.6) | (33.5–48.2) | 103 (36.9) | (28.6–46.1) | 55 (48.3) | (35.4–61.4) |
| Chronic metabolic disease | 136 (36.7) | (29.6–44.3) | 88 (32.6) | (24.6–41.9) | 48 (45.1) | (32.3–58.5) |
| Diabetes | 115 (30.9) | (24.3–38.3) | 72 (24.7) | (17.8–33.3) | 43 (43.6) | (31.0–57.2) |
| Chronic lung disease | 125 (26.7) | (20.6–33.9) | 88 (26.6) | (19.5–35.3) | 37 (26.9) | (16.6–40.6) |
| Asthma | 92 (18.3) | (13.3–24.7) | 66 (17.4) | (11.9–24.8) | 26 (20.2) | (11.1–33.9) |
| Cardiovascular disease¶ | 45 (13.3) | (8.7–19.9) | 27 (8.4) | (4.8–14.4) | 18 (23.5) | (13.0–38.6) |
| Pregnancy (n = 189)** | 34 (9.6) | (6.5–14.0) | 22 (9.5) | (5.8–15.2) | 12 (9.7) | (4.9–18.4) |
| Immunocompromised condition | 28 (7.0) | (4.1–11.8) | 17 (6.7) | (3.5–12.5) | 11 (7.7) | (2.9–19.0) |
|
| ||||||
| Any symptoms | 411 (96.6) | (94.4–98.0) | 276 (96.4) | (93.1–98.1) | 135 (97.1) | (94.5–98.5) |
| Shortness of breath | 339 (79.0) | (72.0–84.5) | 226 (77.9) | (69.1–84.7) | 113 (81.2) | (68.8–89.5) |
| Cough | 324 (76.6) | (69.7–82.3) | 218 (75.1) | (66.2–82.3) | 106 (79.8) | (68.6–87.7) |
| Fever/Chills | 323 (73.9) | (66.7–80.1) | 220 (75.0) | (66.0–82.2) | 103 (71.8) | (58.6–82.2) |
| Muscle aches/Myalgias | 177 (35.9) | (29.2–43.3) | 126 (38.4) | (30.0–47.5) | 51 (30.9) | (20.4–43.8) |
| Nausea/Vomiting | 145 (31.6) | (25.0–39.1) | 99 (33.8) | (25.5–43.1) | 46 (27.2) | (17.3–40.1) |
| Headache | 123 (29.3) | (22.8–36.7) | 79 (27.6) | (20.0–36.8) | 44 (32.8) | (21.7–46.2) |
| Diarrhea | 114 (24.8) | (19.1–31.4) | 75 (27.7) | (20.4–36.5) | 39 (18.6) | (11.9–28.0) |
| Chest pain | 105 (23.9) | (18.0–31.0) | 67 (25.6) | (18.2–34.8) | 38 (20.5) | (12.3–32.2) |
| Congested/Runny nose | 65 (14.6) | (10.2–20.5) | 46 (14.5) | (9.4–21.8) | 19 (14.8) | (7.6–26.8) |
| Sore throat | 66 (14.2) | (9.7–20.3) | 51 (17.1) | (11.1–25.4) | 15 (8.1) | (3.6–17.2) |
| Abdominal pain | 46 (12.4) | (8.1–18.6) | 32 (13.3) | (7.9–21.3) | 14 (10.8) | (4.9–21.9) |
| Anosmia/Decreased smell | 40 (9.4) | (5.7–15.1) | 26 (11.4) | (6.3–19.7) | 14 (5.2) | (2.6–10.1) |
| Dysgeusia/Decreased taste | 36 (6.8) | (4.0–11.6) | 20 (5.7) | (2.6–12.1) | 16 (9.2) | (4.4–18.3) |
| Wheezing | 29 (5.7) | (3.2–10.1) | 19 (4.6) | (2.1–9.6) | 10 (8.2) | (3.3–18.9) |
|
| 4 (3–9) | — | 4 (2–9) | — | 5 (3–9) | — |
|
| ||||||
| Infiltrate/Consolidation | 288 (86.9) | (79.3–92.0) | 201 (91.4) | (84.3–95.5) | 87 (76.8) | (58.9–88.4) |
| Bronchopneumonia/Pneumonia | 84 (32.0) | (24.1–41.0) | 58 (35.1) | (25.3–46.3) | 26 (24.9) | (13.9–40.5) |
| Pleural effusion | 11 (6.3) | (3.0–13.1) | 5 (2.6) | (0.8–7.6) | 6 (14.8) | (5.8–33.0) |
|
| ||||||
| Infiltrate/Consolidation | 56 (61.2) | (45.4–75.0) | 38 (53.5) | (34.9–71.1) | 18 (77.0) | (47.4–92.6) |
| Ground glass opacities | 57 (59.9) | (44.0–73.9) | 40 (61.4) | (42.4–77.5) | 17 (56.7) | (29.5–80.3) |
| Bronchopneumonia/Pneumonia | 41 (46.5) | (31.5–62.2) | 29 (41.0) | (24.1–60.2) | 12 (57.9) | (31.7–80.4) |
| Pleural effusion | 10 (9.3) | (3.4–23.2) | 9 (10.7) | (3.3–29.8) | 1 (6.4) | (0.9–34.7) |
|
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| Received treatment | 212 (48.2) | (40.8–55.8) | 140 (47.5) | (38.5–56.7) | 72 (49.8) | (36.8–62.8) |
| Hydroxychloroquine§§ | 152 (35.5) | (28.8–42.8) | 96 (35.4) | (27.3–44.4) | 56 (35.6) | (24.4–48.6) |
| Azithromycin¶¶ | 104 (25.9) | (19.8–32.9) | 71 (25.6) | (18.6–34.2) | 33 (26.3) | (16.2–39.8) |
| Remdesivir | 54 (10.6) | (7.1–15.6) | 43 (11.0) | (7.0–17.0) | 11 (9.8) | (4.2–21.2) |
| Vitamins/minerals (i.e., vitamin C, zinc) | 14 (8.9) | (5.0–15.6) | 12 (10.4) | (5.4–19.0) | 2 (6.0) | (1.5–20.8) |
| IL–6 inhibitors (i.e., tocilizumab, sarilumab) | 46 (8.2) | (5.6–12.0) | 24 (5.6) | (3.2–9.4) | 22 (13.7) | (7.8–23.0) |
| Convalescent plasma | 19 (5.1) | (2.5–10.0) | 14 (5.4) | (2.4–11.4) | 5 (4.5) | (1.0–17.7) |
| Protease inhibitors (i.e., atazanavir, lopinavir/ritonavir)*** | 8 (1.7) | (0.6–4.3) | 4 (0.6) | (0.2–1.5) | 4 (4.0) | (1.2–12.5) |
| Other††† | 8 (1.7) | (0.6–4.2) | 8 (2.5) | (0.9–6.2) | — | — |
|
| 116 (27.5) | (21.3–34.7) | 80 (29.6) | (21.9–38.6) | 36 (23.2) | (14.2–35.6) |
| ICU length of stay (median days, IQR) | 6 (3–20) | — | 6 (4–19) | — | 5 (3–21) | — |
|
| ||||||
| Invasive mechanical ventilation¶¶¶ | 65 (15.8) | (11.1–22.0) | 44 (15.6) | (10.2–23.1) | 21 (16.3) | (8.5–28.9) |
| BIPAP/CPAP¶¶¶ | 13 (2.4) | (1.2–5.0) | 9 (3.1) | (1.3–7.0) | 4 (1.2) | (0.4–3.1) |
| High flow nasal cannula¶¶¶ | 28 (5.2) | (2.8–9.6) | 21 (6.8) | (3.4–13.2) | 7 (2.0) | (0.9–4.3) |
| Systemic steroids | 74 (17.7) | (12.6–24.1) | 47 (16.9) | (11.1–24.9) | 27 (19.2) | (10.9–31.7) |
| Vasopressor (n = 436) | 60 (14.4) | (10.0–20.3) | 41 (15.2) | (9.9–22.8) | 19 (12.8) | (6.4–23.9) |
| Renal replacement therapy | 13 (2.1) | (1.0–4.6) | 9 (1.9) | (0.8–4.8) | 4 (2.6) | (0.7–9.7) |
|
| ||||||
| Pneumonia (n = 437) | 213 (56.7) | (49.3–63.8) | 148 (56.8) | (47.7–65.4) | 65 (56.5) | (43.5–68.7) |
| Acute respiratory failure | 170 (42.9) | (35.6–50.6) | 117 (45.9) | (36.8–55.2) | 53 (36.8) | (25.1–50.2) |
| Sepsis (n = 437) | 63 (13.2) | (9.0–18.8) | 44 (14.9) | (9.6–22.4) | 19 (9.6) | (4.4–19.6) |
| Acute renal failure (n = 437) | 46 (9.7) | (6.4–14.3) | 28 (7.7) | (4.6–12.5) | 18 (13.7) | (7.1–24.8) |
| Acute respiratory distress syndrome (n = 437) | 38 (9.0) | (5.5–14.4) | 24 (7.8) | (4.3–13.7) | 14 (11.5) | (4.9–24.3) |
| Deep vein thrombosis (n = 159) | 6 (7.4) | (2.9–17.4) | 4 (7.9) | (2.7–21.0) | 2 (6.3) | (1.0–30.1) |
| Pulmonary embolism (n = 159) | 6 (6.0) | (2.5–14.0) | 5 (7.7) | (2.9–18.8) | 1 (2.5) | (0.3–15.8) |
|
| 16 (4.2) | (2.2–7.7) | 11 (4.1) | (1.9–8.6) | 5 (4.3) | (1.4–12.5) |
Abbreviations: BIPAP = bilevel positive airway pressure; CI = confidence interval; COVID–19 = coronavirus disease 2019; COVID–NET = COVID–19–Associated Hospitalization Surveillance Network; CPAP = continuous positive airway pressure; CT = computed tomography; ICU = intensive care unit; IQR = interquartile range; MRI = magnetic resonance imaging.
* Reported HCP were categorized as those generally expected and those generally not expected to have direct patient contact based on HCP type.
† Sites located in the following 13 states: California, Colorado, Connecticut, Georgia, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah.
§ Defined as any of the following: chronic lung disease, chronic metabolic disease, blood disorder/hemoglobinopathy, cardiovascular disease, neurologic disorder, immunocompromised condition, renal disease, gastrointestinal/liver disease, rheumatologic/autoimmune/inflammatory condition, obesity (body mass index ≥30 kg/m2), and pregnancy.
¶ Excluding hypertension.
** Pregnancy was assessed among female patients aged 18–49 years; two pregnant patients were admitted to the ICU, and one required invasive mechanical ventilation.
†† Assessed as nonmutually exclusive treatment categories.
§§ Includes treatments administered as off–label, for compassionate use, or as part of randomized controlled trials (RCTs) for which the patient might have received treatment or a placebo: hydroxychloroquine (two), remdesivir (six), tocilizumab (one), and sarilumab (two).
¶¶ Given with at least one other COVID-19 investigational treatment.
*** Not given for human immunodeficiency virus infection.
††† Eight patients received at least one of the following treatments: RCT for baricitinib (three), dexamethasone (three), cyclosporine (one), RCT for losartan (one), and RCT for LY3127804 (one).
§§§ Five (1.9%) patients received extracorporeal membrane oxygenation, and two (0.2%) received intravenous immunoglobulin.
¶¶¶ Highest level of respiratory support for each patient that needed respiratory support.
FIGURE 2Weighted percentage of personnel types*, among reported health care personnel (HCP) with COVID-19–associated hospitalizations (N = 438) — COVID–NET, 13 states, March 1–May 31, 2020
Abbreviations: CNA = certified nursing assistant; COVID-19 = coronavirus disease 2019; COVID–NET = COVID–19–Associated Hospitalization Surveillance Network; EMS = emergency medical services; HR = human resources; LTCF = long-term care facility; OT = occupational therapist; PCA = patient care assistant; PT = physical therapist.
* HCP categorized as “unspecified” or “other” have not been included in the figure but are included in the denominator.
† Error bars represent 95% confidence intervals.
§ Sites located in the following 13 states: California, Colorado, Connecticut, Georgia, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah.