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Literature DB >> 33115882

The beneficial and pathogenic roles of complement in COVID-19.

Alfred H J Kim¹, Xiaobo Wu¹, John P Atkinson².

Abstract

We briefly summarize the complement system and its functions in immunity and disease. We present data supporting the requirement of complement to resolve COVID-19, and discuss how complement overactivation later in severe disease could drive multiorgan damage characteristic of fatal COVID-19.

Entities: Chemical

Year: 2020 PMID： 33115882 PMCID： PMC8079550 DOI： 10.3949/ccjm.87a.ccc065

Source DB: PubMed Journal: Cleve Clin J Med ISSN： 0891-1150 Impact factor: 2.321

13 in total

Review 1. The complement system in COVID-19: friend and foe?

Authors: Anuja Java; Anthony J Apicelli; M Kathryn Liszewski; Ariella Coler-Reilly; John P Atkinson; Alfred Hj Kim; Hrishikesh S Kulkarni
Journal: JCI Insight Date: 2020-08-06

Review 2. Complement's hidden arsenal: New insights and novel functions inside the cell.

Authors: M Kathryn Liszewski; Michelle Elvington; Hrishikesh S Kulkarni; John P Atkinson
Journal: Mol Immunol Date: 2017-02-10 Impact factor: 4.407

3. Activation of the complement system in the adult respiratory distress syndrome.

Authors: R A Robbins; W D Russ; J K Rasmussen; M M Clayton
Journal: Am Rev Respir Dis Date: 1987-03

Review 4. Complement Dysregulation and Disease: Insights from Contemporary Genetics.

Authors: M Kathryn Liszewski; Anuja Java; Elizabeth C Schramm; John P Atkinson
Journal: Annu Rev Pathol Date: 2016-12-05 Impact factor: 23.472

Review 5. Complement and viral pathogenesis.

Authors: Kristina A Stoermer; Thomas E Morrison
Journal: Virology Date: 2011-02-02 Impact factor: 3.616

6. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101.

Authors: Sara Mastaglio; Annalisa Ruggeri; Antonio M Risitano; Piera Angelillo; Despina Yancopoulou; Dimitrios C Mastellos; Markus Huber-Lang; Simona Piemontese; Andrea Assanelli; Cecilia Garlanda; John D Lambris; Fabio Ciceri
Journal: Clin Immunol Date: 2020-04-29 Impact factor: 3.969

7. Terminal complement inhibition dampens the inflammation during COVID-19.

Authors: Austin G Kulasekararaj; Ioanna Lazana; Joanna Large; Kristina Posadas; Helen Eagleton; John Lord Villajin; Mark Zuckerman; Shreyans Gandhi; Judith C W Marsh
Journal: Br J Haematol Date: 2020-06-28 Impact factor: 8.615

8. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.

Authors: Cynthia Magro; J Justin Mulvey; David Berlin; Gerard Nuovo; Steven Salvatore; Joanna Harp; Amelia Baxter-Stoltzfus; Jeffrey Laurence
Journal: Transl Res Date: 2020-04-15 Impact factor: 7.012

9. Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

Authors: Lisa E Gralinski; Timothy P Sheahan; Thomas E Morrison; Vineet D Menachery; Kara Jensen; Sarah R Leist; Alan Whitmore; Mark T Heise; Ralph S Baric
Journal: mBio Date: 2018-10-09 Impact factor: 7.867

10. Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy.

Authors: Dimitrios C Mastellos; Bruno G P Pires da Silva; Benedito A L Fonseca; Natasha P Fonseca; Maria Auxiliadora-Martins; Sara Mastaglio; Annalisa Ruggeri; Marina Sironi; Peter Radermacher; Akrivi Chrysanthopoulou; Panagiotis Skendros; Konstantinos Ritis; Ilenia Manfra; Simona Iacobelli; Markus Huber-Lang; Bo Nilsson; Despina Yancopoulou; E Sander Connolly; Cecilia Garlanda; Fabio Ciceri; Antonio M Risitano; Rodrigo T Calado; John D Lambris
Journal: Clin Immunol Date: 2020-09-19 Impact factor: 3.969

3 in total

1. Metabolite, protein, and tissue dysfunction associated with COVID-19 disease severity.

Authors: Ali Rahnavard; Brendan Mann; Abhigya Giri; Ranojoy Chatterjee; Keith A Crandall
Journal: Sci Rep Date: 2022-07-16 Impact factor: 4.996

2. DEspR^high neutrophils are associated with critical illness in COVID-19.

Authors: Joanne T deKay; Ivette F Emery; Jonathan Rud; Ashley Eldridge; Christine Lord; David J Gagnon; Teresa L May; Victoria L M Herrera; Nelson Ruiz-Opazo; Richard R Riker; Douglas B Sawyer; Sergey Ryzhov; David B Seder
Journal: Sci Rep Date: 2021-11-17 Impact factor: 4.996

Review 3. A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency.

Authors: Elizabeth M Sajdel-Sulkowska
Journal: Front Pharmacol Date: 2021-06-11 Impact factor: 5.810

3 in total