Yuming Chong1, Chang Han2, Ji Li3, Xiao Long1. 1. Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. 2. Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. 3. Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Abstract
BACKGROUND: Inflammatory bowel disease (IBD) represents a series of digestive system abnormalities and parenteral manifestations. Stem cell therapy has been regarded as a promising treatment for IBD. METHODS: We searched Web of Science Core Collection for publications of interest from 1991 to 2019. Publication performance was analyzed using several bibliometric parameters, including Statplanet to reveal the geographic distribution of the publications, VOSviewer to identify the research landscape of hot topics, and CiteSpace to show keywords with the strongest citation bursts. RESULTS: A total of 1230 publications were identified, of which 674 articles were analyzed further. The United States was the most productive country and Spanish researchers published the highest quality articles. At a journal level, Gastroenterology published the greatest number of articles, while articles from Gut had the highest citation number. Results from the research landscape analysis of hot topics and the top 20 terms with the strongest citation bursts indicated that animal experiments, immunocytes, intestinal epithelial cells, cytokine expression, and clinical efficacy were the main focuses of research. CONCLUSION: Stem cell therapy for IBD is currently receiving increasing attention by researchers, with focuses on animal experiments, immunocytes, intestinal epithelial cells, cytokine expression, and clinical efficacy.
BACKGROUND:Inflammatory bowel disease (IBD) represents a series of digestive system abnormalities and parenteral manifestations. Stem cell therapy has been regarded as a promising treatment for IBD. METHODS: We searched Web of Science Core Collection for publications of interest from 1991 to 2019. Publication performance was analyzed using several bibliometric parameters, including Statplanet to reveal the geographic distribution of the publications, VOSviewer to identify the research landscape of hot topics, and CiteSpace to show keywords with the strongest citation bursts. RESULTS: A total of 1230 publications were identified, of which 674 articles were analyzed further. The United States was the most productive country and Spanish researchers published the highest quality articles. At a journal level, Gastroenterology published the greatest number of articles, while articles from Gut had the highest citation number. Results from the research landscape analysis of hot topics and the top 20 terms with the strongest citation bursts indicated that animal experiments, immunocytes, intestinal epithelial cells, cytokine expression, and clinical efficacy were the main focuses of research. CONCLUSION: Stem cell therapy for IBD is currently receiving increasing attention by researchers, with focuses on animal experiments, immunocytes, intestinal epithelial cells, cytokine expression, and clinical efficacy.
Authors: Sara M Melief; Ellen Schrama; Martijn H Brugman; Machteld M Tiemessen; Martin J Hoogduijn; Willem E Fibbe; Helene Roelofs Journal: Stem Cells Date: 2013-09 Impact factor: 6.277
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Authors: Isabelle Cleynen; Juan R González; Carolina Figueroa; Andre Franke; Dermot McGovern; Martin Bortlík; Bart J A Crusius; Maurizio Vecchi; Marta Artieda; Magdalena Szczypiorska; Johannes Bethge; David Arteta; Edgar Ayala; Silvio Danese; Ruud A van Hogezand; Julian Panés; Salvador Amado Peña; Milan Lukas; Derek P Jewell; Stefan Schreiber; Severine Vermeire; Miquel Sans Journal: Gut Date: 2012-12-21 Impact factor: 23.059
Authors: Suna Onengut-Gumuscu; Wei-Min Chen; Oliver Burren; Nick J Cooper; Aaron R Quinlan; Josyf C Mychaleckyj; Emily Farber; Jessica K Bonnie; Michal Szpak; Ellen Schofield; Premanand Achuthan; Hui Guo; Mary D Fortune; Helen Stevens; Neil M Walker; Lucas D Ward; Anshul Kundaje; Manolis Kellis; Mark J Daly; Jeffrey C Barrett; Jason D Cooper; Panos Deloukas; John A Todd; Chris Wallace; Patrick Concannon; Stephen S Rich Journal: Nat Genet Date: 2015-03-09 Impact factor: 38.330