Literature DB >> 3311496

Effect of cyclosporin A on autoimmune tubulointerstitial nephritis in the brown Norway rat.

A Giménez1, F Leyva-Cobián, C Fierro, M Río, T Bricio, F Mampaso.   

Abstract

The effect of cyclosporin A (CyA) on the development of tubulointerstitial nephritis (TIN) in the brown Norway (BN) rat was assessed. All manifestations of TIN were prevented in rats by subcutaneously injected CyA (20 mg/kg/day). A short 7-day course of CyA beginning the day before immunization suppressed the primary and ongoing antibody response. In addition, delayed CyA treatment (starting on day 10 after immunization), when antibody response was established, drastically reduced the levels of serum anti-TBM IgG, and abrogated the interstitial inflammatory cell response, in spite of persistent kidney-bound TBM antibodies. These results indicate that CyA has a therapeutic effect on the BN rat model of TIN.

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Year:  1987        PMID： 3311496      PMCID： PMC1542380     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  21 in total

1.  Role of sensitized cells in antitubular basement membrane interstitial nephritis.

Authors:  D H Lehman; C B Wilson
Journal:  Int Arch Allergy Appl Immunol       Date:  1976

2.  Successful treatment of autoimmunity in (NZB X NZW)F1 mice with cyclosporin and (Nva2)-cyclosporin: II. Reduction of glomerulonephritis.

Authors:  H C Gunn; B Ryffel
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

Review 3.  Immunosuppression for organ grafting -- observations on cyclosporin A.

Authors:  R Y Calne
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

4.  Interstitial nephritis in rats immunized with heterologous tubular basement membrane.

Authors:  D H Lehman; C B Wilson; F J Dixon
Journal:  Kidney Int       Date:  1974-03       Impact factor: 10.612

Review 5.  Cyclosporin A--usefulness, risks and mechanism of action.

Authors:  S Britton; R Palacios
Journal:  Immunol Rev       Date:  1982       Impact factor: 12.988

Review 6.  Mechanism of T cell activation: role and functional relationship of HLA-DR antigens and interleukins.

Authors:  R Palacios
Journal:  Immunol Rev       Date:  1982       Impact factor: 12.988

7.  Immunosuppressive effect of cyclosporin A in two lymphocyte transfer models in rats: comparison of in vivo and in vitro treatment.

Authors:  B Ryffel; C Feurer; B Heuberger; J F Borel
Journal:  Immunobiology       Date:  1982-12       Impact factor: 3.144

8.  Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

Authors:  J F Borel; C Feurer; C Magnée; H Stähelin
Journal:  Immunology       Date:  1977-06       Impact factor: 7.397

9.  Cyclosporin A to prevent graft-versus-host disease in man after allogeneic bone-marrow transplantation.

Authors:  R L Powles; H M Clink; D Spence; G Morgenstern; J G Watson; P J Selby; M Woods; A Barrett; B Jameson; J Sloane; S D Lawler; H E Kay; D Lawson; T J McElwain; P Alexander
Journal:  Lancet       Date:  1980-02-16       Impact factor: 79.321

10.  Characterization of anti-tubular basement membrane antibodies in rats.

Authors:  M Zanetti; C B Wilson
Journal:  J Immunol       Date:  1983-05       Impact factor: 5.422
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  3 in total

1.  Cyclosporin A in the prevention and treatment of experimental autoimmune glomerulonephritis in the brown Norway rat.

Authors:  J Reynolds; S J Cashman; D J Evans; C D Pusey
Journal:  Clin Exp Immunol       Date:  1991-07       Impact factor: 4.330

Review 2.  Inflammation and glomerular injury.

Authors:  A Benigni; G Remuzzi
Journal:  Springer Semin Immunopathol       Date:  1994

Review 3.  Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.

Authors:  Diana Faulds; Karen L Goa; Paul Benfield
Journal:  Drugs       Date:  1993-06       Impact factor: 9.546
  3 in total

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