Literature DB >> 33111433

Clinical manifestations and factors associated with mortality from COVID-19 in older adults: Retrospective population-based study with 9807 older Brazilian COVID-19 patients.

Carlos Df de Souza1, Amanda J de Arruda Magalhães2, Ayara Jpd Lima2, Danielle N Nunes2, Érika de Fátima Machado Soares2, Louryanne de Castro Silva2, Lucas G Santos2, Vitória I Dos Santos Cardoso2, Yasmin Vs Nobre2, Rodrigo F do Carmo3,4.   

Abstract

AIM: Older adults are the main risk group for coronavirus disease 2019 (COVID-19). This study aimed to describe the clinical manifestations and factors associated with mortality from COVID-19 among older adults in Brazil.
METHODS: A cross-sectional observational study was carried out with data from 9807 cases of COVID-19 among older adults in the state of Alagoas, Brazil. We determined the case fatality rate between age groups and clinical factors associated with mortality.
RESULTS: A total of 52.5% (n = 5145) were women, and with an average age of 70.21 ± 8.37 years. The fatality rate was 11.9%, with a higher rate in men (14.4%) compared with women (9.8%). The fatality rate increased with age. The most common manifestations were fever (n = 4926; 50.2%), cough (n = 5737; 58.5%), headache (n = 1980; 20.2%) and fatigue (n = 2022; 20.6%). The most prevalent comorbidities were diabetes (n = 1528; 5.6%), cardiovascular disease (n = 1528; 15.6%) and systemic arterial hypertension (n = 597; 6.1%). The factors associated with mortality were male sex (OR 1.54), age ≥75 years (OR 2.40), dyspnea (OR 2.92), diabetes (OR 2.33), hypertension (OR 1.53) and chronic kidney disease (OR 2.02).
CONCLUSIONS: The profile and the risk factors evidenced show the need to adopt mechanisms to protect the elderly population.
© 2020 Japan Geriatrics Society.

Entities:  

Keywords:  COVID-19; elderly; geriatric patients; mortality; risk factors

Year:  2020        PMID: 33111433     DOI: 10.1111/ggi.14061

Source DB:  PubMed          Journal:  Geriatr Gerontol Int        ISSN: 1447-0594            Impact factor:   2.730


  7 in total

Review 1.  Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences.

Authors:  Reem Hoteit; Hadi M Yassine
Journal:  Vaccines (Basel)       Date:  2022-06-09

Review 2.  Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis.

Authors:  Abraham Degarege; Zaeema Naveed; Josiane Kabayundo; David Brett-Major
Journal:  Pathogens       Date:  2022-05-10

Review 3.  COVID-19 and chronic kidney disease: an updated overview of reviews.

Authors:  Sara S Jdiaa; Razan Mansour; Abdallah El Alayli; Archana Gautam; Preston Thomas; Reem A Mustafa
Journal:  J Nephrol       Date:  2022-01-11       Impact factor: 3.902

4.  Risk assessment and rationalization of health resource allocation: Lessons from the Brazilian COVID-19 cohort in 2020.

Authors:  Vitória Berg Cattani; Thaís Araujo Dos Santos; Julio Castro-Alves; Marcelo Ribeiro-Alves
Journal:  Prev Med Rep       Date:  2022-02-02

5.  An observational study to find association between Hypertension and severe and fatal COVID-19 infection in COVID dedicated hospital, Mumbai.

Authors:  Kirti V Kinge; Smita S Chavhan; Balkrishna B Adsul; Maharudra A Kumbhar; Chinmay N Gokhale; Aniket R Ingale
Journal:  J Family Med Prim Care       Date:  2022-01-31

Review 6.  Factors Associated for Mortality of Older People With COVID 19: A Systematic Review and Meta-analysis.

Authors:  H D W T Damayanthi; K I P Prabani; Ishanka Weerasekara
Journal:  Gerontol Geriatr Med       Date:  2021-12-01

7.  Reply to comment on "Unexpected decline in glycated hemoglobin level after emergency COVID-19 measures in three robust older Japanese women with prediabetes/mild type 2 diabetes".

Authors:  Tazuo Okuno; Osamu Iritani; Kumie Kodera; Daisuke Hama; Asami Kane; Kozue Morigaki; Toshio Terai; Norie Maeno; Shigeto Morimoto
Journal:  Geriatr Gerontol Int       Date:  2022-05-13       Impact factor: 3.387

  7 in total

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