Fernando Henao1, Aranzazu Manzano2, Rafael Lopez Lopez3, Ana Luisa Gobartt4, Ramón de Las Peñas5. 1. Medical Oncology Department, Hospital Universitario Virgen Macarena, Calle Dr. Fedriani, 3, 41009, Seville, Spain. 2. Service of Medical Oncology, Hospital Clínico San Carlos, Calle del Prof Martín Lagos, s/n, 28040, Madrid, Spain. 3. Department of Oncology-CIBERONC, Complejo Hospitalario Universitario de Santiago, Rúa da Choupana, s/n, 15706, Santiago de Compostela, Spain. 4. Medical Manager Hospital Unit, Otsuka Pharmaceuticals SA, Avenida Diagonal, 615, 08025, Barcelona, Spain. 5. Department of Oncology, Consorcio Hospitalario Provincial de Castellón, Avenida Doctor Clara, 19, 12002, Castelló, Spain. ramon.delaspenas@hospitalprovincial.es.
Abstract
INTRODUCTION: The ALGA study explored adherence of Spanish treatment centers to the Sociedad Española de Oncología Médica (SEOM) treatment algorithm for oncology patients with hyponatremia that requires treatment as the main cause of hospitalization, and evaluated the impact of adherence to this algorithm on patient outcomes. METHODS: This retrospective study recruited patients aged at least 18 years with cancer, treated for at least one episode of hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The primary outcome was the proportion of patients whose treatment adhered to the SEOM algorithm, evaluated using a pre-defined decision tree. Secondary outcomes included length of hospitalization, and time to serum sodium level improvement. Perceived center adherence to the SEOM algorithm was also assessed. RESULTS: Seventy patients from four treatment centers were included. Twenty (28.6%; 95% confidence interval [CI] 18.0, 39.2) patients on hyponatremia treatment adhered to the SEOM algorithm, with a perceived adherence of 51.0-75.0%. Algorithm adherence in candidates for chemotherapy was 36.4% (n = 8) versus 25.0% (n = 12) for non-candidates for chemotherapy. Median time to serum sodium level improvement in patients managed adherently was 80.5 h (95% CI 38.3, 331.4) versus 134.6 h (33.2, 444.9) in patients managed non-adherently. Median time to hospital discharge was 16.5 days (95% CI 8.0, 27.0) in patients managed adherently versus 9.5 days (7.0, 22.0) in patients managed non-adherently. CONCLUSION: In Spanish centers, the SEOM algorithm was adhered to in less than one-third of patients, in contrast to higher levels of perceived adherence. This requires further investigation; however, algorithm use could require further clarification, especially in non-candidates for chemotherapy.
INTRODUCTION: The ALGA study explored adherence of Spanish treatment centers to the Sociedad Española de Oncología Médica (SEOM) treatment algorithm for oncology patients with hyponatremia that requires treatment as the main cause of hospitalization, and evaluated the impact of adherence to this algorithm on patient outcomes. METHODS: This retrospective study recruited patients aged at least 18 years with cancer, treated for at least one episode of hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The primary outcome was the proportion of patients whose treatment adhered to the SEOM algorithm, evaluated using a pre-defined decision tree. Secondary outcomes included length of hospitalization, and time to serum sodium level improvement. Perceived center adherence to the SEOM algorithm was also assessed. RESULTS: Seventy patients from four treatment centers were included. Twenty (28.6%; 95% confidence interval [CI] 18.0, 39.2) patients on hyponatremia treatment adhered to the SEOM algorithm, with a perceived adherence of 51.0-75.0%. Algorithm adherence in candidates for chemotherapy was 36.4% (n = 8) versus 25.0% (n = 12) for non-candidates for chemotherapy. Median time to serum sodium level improvement in patients managed adherently was 80.5 h (95% CI 38.3, 331.4) versus 134.6 h (33.2, 444.9) in patients managed non-adherently. Median time to hospital discharge was 16.5 days (95% CI 8.0, 27.0) in patients managed adherently versus 9.5 days (7.0, 22.0) in patients managed non-adherently. CONCLUSION: In Spanish centers, the SEOM algorithm was adhered to in less than one-third of patients, in contrast to higher levels of perceived adherence. This requires further investigation; however, algorithm use could require further clarification, especially in non-candidates for chemotherapy.
Authors: Goce Spasovski; Raymond Vanholder; Bruno Allolio; Djillali Annane; Steve Ball; Daniel Bichet; Guy Decaux; Wiebke Fenske; Ewout J Hoorn; Carole Ichai; Michael Joannidis; Alain Soupart; Robert Zietse; Maria Haller; Sabine van der Veer; Wim Van Biesen; Evi Nagler Journal: Eur J Endocrinol Date: 2014-02-25 Impact factor: 6.664
Authors: Fabio A B Schutz; Wanling Xie; Frede Donskov; Monica Sircar; David F McDermott; Brian I Rini; Neeraj Agarwal; Sumanta Kumar Pal; Sandy Srinivas; Christian Kollmannsberger; Scott A North; Lori A Wood; Ulka Vaishampayan; Min-Han Tan; Mary J Mackenzie; Jae Lyun Lee; Sun-Young Rha; Takeshi Yuasa; Daniel Y C Heng; Toni K Choueiri Journal: Eur Urol Date: 2013-10-26 Impact factor: 20.096
Authors: Daniele Santini; Raffaele Ratta; Francesco Pantano; Delia De Lisi; Marco Maruzzo; Luca Galli; Elisa Biasco; Azzurra Farnesi; Sebastiano Buti; Cora Nanette Sternberg; Linda Cerbone; Giuseppe Di Lorenzo; Silvia Spoto; Michelle Sterpi; Ugo De Giorgi; Rossana Berardi; Mariangela Torniai; Andrea Camerini; Francesco Massari; Giuseppe Procopio; Giuseppe Tonini Journal: Oncotarget Date: 2017-08-07