Literature DB >> 33104973

Panton-Valentine leukocidin (PVL) isoforms among Staphylococcus aureus lineages isolated from hospitals in Rio de Janeiro, Brazil.

Raiane Cardoso Chamon1,2, Tamara Lopes Rocha de Oliveira2, Rosana Barreto Rocha Ferreira2, Lilian Oliveira Moreira3, Kátia Regina Netto Dos Santos4.   

Abstract

Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus virulence factor codified by lukSF-PV genes. Single-nucleotide polymorphisms (SNPs) at lukSF-PV genes can lead to two PVL sequence variants (R and H) generating different PVL isoforms. This study analyzed lukSF-PV genes SNPs among four different clonal lineages (STs/CC 1, 5, 8, and 30) of nine S. aureus isolated at Brazilian hospitals. The sequenced products showed SNPs at seven sites (positions 121, 470, 527, 663, 856, 1396, and 1729), leading to non-synonymous substitutions in all isolates investigated. Our findings showed new R and H isoforms variants in S. aureus isolated in Brazil and suggest a possible relationship between H2b isoform and the ST30/CC30 lineage.

Entities:  

Keywords:  Brazilian lineages; Panton-Valentine leukocidin (PVL) isoforms; Staphylococcus aureus

Mesh：

Substances：

Year:  2020        PMID： 33104973      PMCID： PMC7688806          DOI： 10.1007/s42770-020-00386-y

Source DB:  PubMed          Journal:  Braz J Microbiol        ISSN： 1517-8382            Impact factor:   2.476


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