Falling Dynamics of SARS-CoV-2 as a Function of Respiratory Droplet Size and Human Height.

PURPOSE: The purpose of this study is to quantify the motion dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
METHODS: Three physical models of Newton's and Stokes's laws with(out) air resistance in the calm air are used to determine the falling time and velocity regimes of SARS-CoV-2 with(out) a respiratory water droplet of 1 to 2000 micrometers (µm) in diameter of an infected person of 0.5 to 2.6 m in height.
RESULTS: The horizontal distance travelled by SARS-CoV-2 in free fall from 1.7 m was 0.88 m due to breathing or talking and 2.94 m due to sneezing or coughing. According to Newton's laws of motion with air resistance, its falling velocity and time from 1.7 m were estimated at 3.95 × 10-2 m s-1 and 43 s, respectively. Large droplets > 100 µm reached the ground from 1.7 m in less than 1.6 s, while the droplets ≥ 30 µm fell within 4.42 s regardless of the human height. Based on Stokes's law, the falling time of the droplets encapsulating SARS-CoV-2 ranged from 4.26 × 10-3 to 8.83 × 104 s as a function of the droplet size and height.
CONCLUSION: The spread dynamics of the COVID-19 pandemic is closely coupled to the falling dynamics of SARS-CoV-2 for which Newton's and Stokes's laws appeared to be applicable mostly to the respiratory droplet size ≥ 237.5 µm and ≤ 237.5 µm, respectively. An approach still remains to be desired so as to better quantify the motion of the nano-scale objects. © Taiwanese Society of Biomedical Engineering 2020.

Introduction

The number of virus particles on the Earth has been recently estimated at close to 1031 [1]. The newly emergent 2019 novel coronavirus (2019-nCoV) disease (COVID-19), whose virus name has been changed by the International Committee on Taxonomy of Viruses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic with serious impacts on the public and environmental health and human welfare. Therefore, it is vital to physically understand and control its spread mechanism. The size of viruses varies between 20 and 300 nanometers (nm) in diameter (1 nm = 10−9 m) [2], while the size of SARS-CoV-2 ranges from 60 to 140 nm in diameter [3]. This brief article aimed to explore three simple physical models to estimate the falling dynamics of SARS-CoV-2 that is transmitted through a respiratory droplet including coughing, sneezing, and expectorating of 1 to 2000 micrometers (µm) in diameter of an infected person of 0.5 to 2.6 m in height. The novelty of this study stems from its first comparative quantification of the falling dynamics of SARS-CoV-2 as a function of respiratory droplet size and human height based on Newton’s and Stokes’s laws.

Physical Models of Falling Dynamics of SARS-CoV-2

In this study, SARS-CoV-2 was assumed as a single particle of a spherical shape with an average diameter of 100 nm, radius of 5.0 × 10−8 m, and a protein density of 1.35 × 103 kg m−3. Whether be encapsulated in a respiratory droplet or not, the volume and mass of the virus can be estimated thus:where , , and are the particle radius (m), mass (kg), and density (kg m−3), respectively. Presented below are the three physical models, namely, one without air resistance (drag) and two with air resistance.

A Free-Falling Particle Without Air Resistance

In Newtonian physics, free fall is the simplest model where gravity is the only force that acts upon a falling particle. The vertical velocity in free fall is expressed as follows:where is the downward velocity (m s−1); is the gravitational acceleration (9.81 m s−2); is falling distance (m); is falling time (s); is the horizontal distance (m); and is the initial velocity of the particle (m s−1).

A Falling Particle with Air Resistance

Not only is a falling particle through the atmosphere exposed to the gravitational force but also to air resistance. Newton’s and Stokes’s laws were used to estimate the falling dynamics of SARS-CoV-2. Based on Newton’s law, the following two forces can be introduced:where is the downwards force due to gravity (Newton); is mass of the falling object (kg); is the air resistance (Newton) in the opposite direction to the velocity of the object; is a shape-dependent coefficient (0.47 for a spherical particle); is the air density (1.2041 kg m−3 at 20 °C and 1 atm); is the cross-surface area of the object (m2); and is the velocity of the particle (m s−1). The air resistance and gravitational forces can be combined in the following equation:where is the net force in the falling/vertical direction according to the Newton’s second law of motion (the net force is defined as the sum of all the forces acting on an object); and is the acceleration of the object (m s−2). This law applies mostly to the macro-scale objects flying with a high speed at the height of at least several meters. Nevertheless, this law may sufficiently reflect the motion of SARS-CoV-2 in the calm air since its initial velocity in the case of sneezing/coughing was reported to be 5.0 m s−1 [4]. Thus, Eq. (9) can be re-arranged as follows:

Assuming that at the final or terminal velocity (, m s−1) yields the following:

Since the acceleration is not constant, the air resistance near the end of the fall is greater than it is at the beginning of the fall. The time for the particles to fall down from a given height () in the calm air can be approximated thus:

As was stated above, a falling particle in a fluid (the air in this study) encounters a frictional resistance proportional to the product of its radius and velocity and to the viscosity of the fluid. The resisting force () due to friction was shown by Stokes in 1851 as follows [5]:where is the viscosity of the fluid, 1.85 × 10−5 kg m−1 s−1, for the dynamical viscosity of air according to Anchordoqui and Chudnovsky [6]. According to Stokes’s law, the terminal/constant velocity is estimated thus [5]:where is the particle diameter (m). A respiratory water droplet encapsulating SARS-CoV-2 can be assumed to have a density () of 997 or 998 kg m−3 (for a droplet 1 µm in diameter). The downward force on a spherical droplet due to gravity can be estimated neglecting the air density thus (please note that ):

Given the conditions of terminal velocity, the following Eqs. can be written:

Assuming that the terminal velocity is attained almost instantly, the falling time () from a height () can be expressed thus:

Using the relevant equations, the falling dynamics of a single isolated SARS-CoV-2 and a respiratory droplet encapsulating it through the atmosphere were simulated as a function of the human heights of 0.5 (the world’s shortest person: 0.54 m), 0.8, 1.1, 1.4, 1.7, 2.0, 2.3, and 2.6 (m) (the world’s tallest person: 2.51 m) and the respiratory droplet size range of 1 to 2000 µm in diameter.

Results and Discussion

The Motion of SARS-CoV-2 Without a Respiratory Droplet

According to Eqs. (1) and (2), the volume and mass of a single SARS-CoV-2 were estimated at 5.236 × 10−22 m3 and 7.07 × 10−19 kg, respectively. In free fall, the mass and shape do not affect the motion. According to Eq. (5), SARS-CoV-2 in free fall from 1.7 m (a typical human height adopted in medical procedures) was estimated to reach the ground in 0.589 s (Fig. 1a). In this case, the corresponding free-fall velocity (5.775 m s−1) is always greater than the real velocity (2.888 m s−1). However, from the physics point of view, a vacuum fall approach cannot be sufficiently justified for the falling velocity of SARS-CoV-2 through the atmosphere. Assuming the velocity of SARS-CoV-2 of 1.5 m s−1 for breathing and talking and of 5.0 m s−1 for sneezing and coughing [4], the horizontal distance travelled by SARS-CoV-2 for a height of 1.7 m was 0.88 m (Fig. 1b) and 2.94 m (Fig. 1c), respectively, based on Eq. (6).

Fig. 1

a Free-fall time of SARS-CoV-2 without a respiratory droplet, and horizontal distance travelled depending on its velocity due to b breathing and talking, and c sneezing and coughing as a function of human height

According to Eqs. (12) and (13) by Newton’s laws of motion, the velocity () and time of a single SARS-CoV-2 falling from the same human height of 1.7 m were estimated at 3.95 × 10−2 m s−1 and 43 s, respectively (Fig. 2a). In these estimates, the cross-surface area for SARS-CoV-2 where a hemispherical surface area is equal to was assumed as 1.571 × 10−14 m2. On the contrary, the downward velocity of a single SARS-CoV-2 through the air (the terminal speed: 3.98 × 10−7 m s−1) is negligible according to Stokes’s law. Using Eqs. (18) and (19), a single SARS-CoV-2 from 1.7 m was estimated to float in the calm air for 49.5 (about 50) days (Fig. 2b). This product of the Stokes’s equation means that the gravity does not play a role in its fall. In other words, an isolated SARS-CoV-2 can stay suspended in the calm air for months. However, the estimated duration is not meant to judge its survival duration in the air. In the above estimates, the interactions between SARS-CoV-2 and droplets were not considered. Despite its negligence by the Stokes’s equation, the gravity force even for a single virus cannot be denied.

Fig. 2

Falling dynamics of SARS-CoV-2 without a respiratory droplet under the gravity with air resistance according to a Newton’s and b Stokes’s laws as a function of human height

The Motion of SARS-CoV-2 with a Respiratory Droplet Under the Gravity with Air Resistance According to Newton’s Law

SARS-CoV-2 is spread through respiratory droplets released from a patient via breathing, talking, coughing, sneezing, or expectorating. Therefore, the velocity and falling time of a single droplet with a single SARS-CoV-2 were estimated as a function of the human height and droplet size using Eqs. (12) and (13), respectively (Fig. 3). Large droplets > 100 µm, as was classified by Chaudhuri et al. [7], reached the ground from 1.7 m in a relatively short period of time < 1.6 s. The droplets 30 µm fell within 4.42 s regardless of the human height (Fig. 3). The droplets with the diameters of 5 and 1 µm from 2.6 m stayed in the calm air for about 11 and 24 s, respectively (Fig. 3).

Fig. 3

Falling time of SARS-CoV-2 with a respiratory droplet under the gravity with air resistance according to Newton’s law as a function of the droplet diameter and human height

The Motion of SARS-CoV-2 with a Respiratory Droplet According to Stokes’s Law

The outputs of Stokes’s law showed a wide range of the falling time of 4.26 × 10−3 s (4.93 × 10−8 days) to 8.83 × 104 s (1.02 days) as a function of the droplet size and height (Fig. 4). This was because the falling time of a spherical particle under the gravity in a fluid of a given density and viscosity is inversely proportional to the square of the particle diameter according to Stokes’s equation. However, there still exists no simple approach that is likely to be applicable to all the situations and to consider all the relevant factors. Our simulations were independent of evaporation, although the micro-scale droplets may rapidly evaporate under low relative humidity, as was reported by Anchordoqui and Chudnovsky [6], Chaudhuri et al. [7], and Wang et al. [8].

Fig. 4

Falling time of SARS-CoV-2 with a respiratory droplet under the gravity with air resistance according to Stokes’s law as a function of the droplet diameter and human height

The predictions of the two physical models show a large variation in the falling time of SARS-CoV-2 encapsulated in a respiratory droplet under the gravity with air resistance. The falling time of SARS-CoV-2 with a droplet diameter of 237.5 µm remained the same between the two models according to the coefficient value of the best-fit simple linear regression without an intercept (Table 1). The coefficients for the other diameters indicate that the falling times predicted by the two models significantly differed, in particular, in terms of the droplet size 100 and 500 µm in diameter.

Table 1

The best-fit simple linear regression models between the falling times of a respiratory droplet with SARS-CoV-2 estimated by Stokes’s (x) and Newton’s (y) equations (r2 = 100%; n = 8; p < 0.05)

Diameter (µm)	Regression equation	Diameter (µm)	Regression equation
1	y = 0.0003x	200	y = 0.7746x
5	y = 0.0031x	300	y = 1.4236x
15	y = 0.0159x	500	y = 3.0557x
30	y = 0.0449x	1000	y = 8.6529x
50	y = 0.0968x	2000	y = 24.489x
100	y = 0.2732x	237.5	y = 1.0003x

The droplet diameter shown in bold led to the same falling time regardless of the two models

The spatiotemporal spread dynamics of the COVID-19 pandemic is closely coupled to the falling dynamics of SARS-CoV-2. The first epidemic analysis was introduced in 1927 using a deterministic method called Susceptible-Infected-Recovered (SIR) [9], whose simplest form is described as a non-linear system of ordinary differential equations. The deterministic models of both spread and falling dynamics generate outputs fully determined by their parameter and initial condition values. However, the statistical physics asserts that any deterministic model can be turned into a stochastic model by introducing even a single random variable in the place of some constants through a random resampling from an underlying statistical distribution. Therefore, the falling dynamics predicted by Newton’s and Stokes’s laws as a function of the human height and droplet size were characterized in terms of their statistical distributions. Both were shown to satisfy the lognormal distributions (AICc = 353.8 and 869.8; Kolmogorov’s D goodness-of-fit test = 0.050 and 0.075; p > 0.15 for Newton’s and Stokes’s laws, respectively) (Fig. 5). The respiratory droplet diameter of 381.9 µm, which can barely pass through a perforated cover of 40 mesh in diameter, and the human height of 1.55 m, which can be assumed as the mouth level of a 1.7-m tall patient, were found as the optimal settings to jointly minimize the falling time of SARS-CoV-2.

Fig. 5

Lognormal probability density and cumulative distribution functions of the falling times of a respiratory droplet with SARS-CoV-2 according to a–b Newton’s and c–d Stokes’s laws, respectively

Conclusion

The estimations in this study without any experimental observations and their validation may not allow for a clear-cut conclusion. Newton’s and Stokes’s laws appeared to be applicable mostly to the droplet size 237.5 µm and 237.5 µm, respectively, in better reflecting the motion of SARS-CoV-2. The droplets of 5 and 1 µm in diameter released from 1.7 m stayed in the calm air for 38.7 min and 16.0 h, respectively, according to the Stokes’s equation. Thus, SARS-CoV-2 encapsulated in such respiratory droplets would go airborne for a long time. This might point to the reason for its quick spread around the world. Therefore, an approach still remains to be desired so as to better quantify and predict the motion of the nano-scale objects.