Xin Dai1, Bing Wei, Yuan He, Qian Zhang, Jianing Xi. 1. Department of Speech Rehabilitation, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing, China.
Abstract
PURPOSE: To observe the postoperative efficacy of low-temperature plasma radiofrequency ablation in treating elderly patients with laryngeal carcinoma and its influence on the tumor markers, cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expressions in laryngeal carcinoma tissues. METHODS: A total of 50 elderly laryngeal carcinoma patients undergoing low-temperature plasma radiofrequency ablation in our hospital from January 2015 to January 2018 were enrolled as observation group, and another 50 elderly laryngeal carcinoma patients receiving conventional surgical treatment as control group. At the end of the treatment course, the efficacy and postoperative complications in the patients were observed, the operation time and pain visual analogue scale (VAS) and mucosal recovery scores were recorded. Besides, the levels of the tumor markers carbohydrate antigen 125 (CA125), CA199 and carcinoembryonic antigen (CEA) were determined, and the expressions of COX-2 and VEGF in laryngeal carcinoma tissues in the two groups were detected using immunohistochemistry and quantitative polymerase chain reaction (PCR). RESULTS: The efficacy in the study group was obviously higher than in the control group (p<0.05), and the cases of postoperative complications declined evidently in the study group (p<0.05). Moreover, the study group exhibited distinctly shorter operation time and lower VAS pain and mucosal recovery scores than the control group (p<0.05). The levels of the tumor markers CA125, CEA and CA19.9 and the expression levels of COX-2 and VEGF in laryngeal carcinoma tissues were substantially lowered in the study group (p<0.05). CONCLUSIONS: Low-temperature plasma radiofrequency ablation has better efficacy in treating elderly laryngeal carcinoma patients, with few postoperative complications, and decreased expression levels of postoperative tumor markers as well as COX-2 and VEGF in laryngeal carcinoma tissues, and it offers better overall effect and notable application value, therefore it is worth trying it in clinical practice.
PURPOSE: To observe the postoperative efficacy of low-temperature plasma radiofrequency ablation in treating elderly patients with laryngeal carcinoma and its influence on the tumor markers, cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) expressions in laryngeal carcinoma tissues. METHODS: A total of 50 elderly laryngeal carcinomapatients undergoing low-temperature plasma radiofrequency ablation in our hospital from January 2015 to January 2018 were enrolled as observation group, and another 50 elderly laryngeal carcinomapatients receiving conventional surgical treatment as control group. At the end of the treatment course, the efficacy and postoperative complications in the patients were observed, the operation time and pain visual analogue scale (VAS) and mucosal recovery scores were recorded. Besides, the levels of the tumor markers carbohydrate antigen 125 (CA125), CA199 and carcinoembryonic antigen (CEA) were determined, and the expressions of COX-2 and VEGF in laryngeal carcinoma tissues in the two groups were detected using immunohistochemistry and quantitative polymerase chain reaction (PCR). RESULTS: The efficacy in the study group was obviously higher than in the control group (p<0.05), and the cases of postoperative complications declined evidently in the study group (p<0.05). Moreover, the study group exhibited distinctly shorter operation time and lower VAS pain and mucosal recovery scores than the control group (p<0.05). The levels of the tumor markers CA125, CEA and CA19.9 and the expression levels of COX-2 and VEGF in laryngeal carcinoma tissues were substantially lowered in the study group (p<0.05). CONCLUSIONS: Low-temperature plasma radiofrequency ablation has better efficacy in treating elderly laryngeal carcinomapatients, with few postoperative complications, and decreased expression levels of postoperative tumor markers as well as COX-2 and VEGF in laryngeal carcinoma tissues, and it offers better overall effect and notable application value, therefore it is worth trying it in clinical practice.
Authors: Vittoria Perrotti; Vito Carlo Alberto Caponio; Lorenzo Lo Muzio; Eun Ha Choi; Maria Carmela Di Marcantonio; Mariangela Mazzone; Nagendra Kumar Kaushik; Gabriella Mincione Journal: Int J Mol Sci Date: 2022-09-06 Impact factor: 6.208