| Literature DB >> 33099377 |
Amos Gilhar1, Rimma Laufer Britva2, Aviad Keren2, Ralf Paus3.
Abstract
The C3H/HeJ model has long dominated basic alopecia areata (AA) in vivo research and has been used as proof-of-principle that Jak inhibitors are suitable agents for AA management in vivo. However, its histologic features are not typical of human AA, and it is questionable whether it is sufficiently clinically predictive for evaluating the therapeutic effects of candidate AA agents. Instead, the humanized mouse model of AA has been used to functionally demonstrate the role of key immune cells in AA pathogenesis and to discover human-specific pharmacologic targets in AA management. Therefore, we advocate the use of both models in future preclinical AA research.Entities:
Mesh：
Year: 2020 PMID： 33099377 PMCID： PMC9393038 DOI： 10.1016/j.jisp.2020.05.001
Source DB: PubMed Journal: J Investig Dermatol Symp Proc ISSN： 1087-0024