Yannick Béjot1, Abderrahmane Bourredjem2,3, Emmanuelle Mimeau4, Julien Joux5, Annie Lannuzel6,7,8,9, Caroline Misslin-Tritsch10, Claire Bonithon-Kopp2,3, Devi Rochemont11, Mathieu Nacher11, André Cabie12,13, Marie-Laure Lalanne Mistrih9, Isabelle Fournel2,3. 1. Dijon Stroke Registry, EA7460, Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases (PEC2), University Hospital of Dijon, University of Burgundy, Dijon, France. 2. INSERM, CIC1432, Clinical Epidemiology Unit, Dijon, France. 3. Clinical Investigation Centre, Clinical Epidemiology/Clinical Trials Unit, Dijon-Bourgogne University Hospital, Dijon, France. 4. Emergency Department, Hospital Andrée Rosemon, Cayenne, French Guiana, France. 5. Neurology Department, University Hospital of Martinique, Fort-de-France, Martinique, France. 6. Neurology Department, University Hospital of Pointe-à-Pitre, Pointe-à-Pitre, France. 7. University of West Indies, Pointe-à-Pitre, France. 8. INSERM U 1127, CNRS, UMR 7225, Institute for Brain and Spinal Cord Disorders, ICM, Sorbonne University, Paris, France. 9. INSERM CIC1424, University Hospital of Pointe-à-Pitre, Pointe à Pitre, France. 10. Medicine Department, Western Guyana Hospital, Saint Laurent du Maroni, France. 11. INSERM CIC1424, Hospital Andrée Rosemon, Cayenne, French Guiana, France. 12. INSERM CIC1424, University Hospital of Martinique, Fort-de-France, Martinique, France. 13. Université des Antilles, EA4537, Fort-de-France, France.
Abstract
BACKGROUND: Social deprivation may have a deleterious influence on post-stroke outcomes, but available data in the literature are mixed. AIM: The aim of this cohort study was to evaluate the impact of social deprivation on 1-year survival in patients with first-ever stroke. METHODS: Social deprivation was assessed at individual level with the EPICES score, a validated multidimensional questionnaire, in 1312 patients with ischemic stroke and 228 patients with spontaneous intracerebral hemorrhage, who were prospectively enrolled in six French study centers. Baseline characteristics including stroke severity and pre-stroke functional status were collected. Multivariable Cox models were generated to evaluate the associations between social deprivation and survival at 12 months in ischemic stroke and intracerebral hemorrhage separately. RESULTS: A total of 819 patients (53.2%) were socially deprived (EPICES score ≥ 30.17). In ischemic stroke, mortality at 12 months was higher in deprived than in non-deprived patients (16% vs. 11%, p = 0.006). In multivariable analyses, there was no association between deprivation and death occurring within the first 90 days following ischemic stroke (adjusted hazard ratio [aHR] 0.81, 95% CI 0.54-1.22, p = 0.32). In contrast, an excess in mortality was observed between 90 days and 12 months in deprived compared with non-deprived patients (aHR 1.97, 95% CI 1.14-3.42, p = 0.016). In patients with intracerebral hemorrhage, mortality at 12 months did not significantly differ according to deprivation status. CONCLUSIONS: Social deprivation was associated with delayed mortality in ischemic stroke patients only and, although the exact underlying mechanisms are still to be identified, our findings suggest that deprived patients in particular may benefit from an optimization of post-stroke care.
BACKGROUND: Social deprivation may have a deleterious influence on post-stroke outcomes, but available data in the literature are mixed. AIM: The aim of this cohort study was to evaluate the impact of social deprivation on 1-year survival in patients with first-ever stroke. METHODS: Social deprivation was assessed at individual level with the EPICES score, a validated multidimensional questionnaire, in 1312 patients with ischemic stroke and 228 patients with spontaneous intracerebral hemorrhage, who were prospectively enrolled in six French study centers. Baseline characteristics including stroke severity and pre-stroke functional status were collected. Multivariable Cox models were generated to evaluate the associations between social deprivation and survival at 12 months in ischemic stroke and intracerebral hemorrhage separately. RESULTS: A total of 819 patients (53.2%) were socially deprived (EPICES score ≥ 30.17). In ischemic stroke, mortality at 12 months was higher in deprived than in non-deprived patients (16% vs. 11%, p = 0.006). In multivariable analyses, there was no association between deprivation and death occurring within the first 90 days following ischemic stroke (adjusted hazard ratio [aHR] 0.81, 95% CI 0.54-1.22, p = 0.32). In contrast, an excess in mortality was observed between 90 days and 12 months in deprived compared with non-deprived patients (aHR 1.97, 95% CI 1.14-3.42, p = 0.016). In patients with intracerebral hemorrhage, mortality at 12 months did not significantly differ according to deprivation status. CONCLUSIONS: Social deprivation was associated with delayed mortality in ischemic strokepatients only and, although the exact underlying mechanisms are still to be identified, our findings suggest that deprived patients in particular may benefit from an optimization of post-stroke care.