Jean-Louis Montastruc1, Geneviève Durrieu1. 1. Service de Pharmacologie Médicale et Clinique, Centre de PharmacoVigilance, de Pharmaco-épidémiologie et d'Informations sur le Médicament de Toulouse, CIC INSERM 1426, Faculté de Médecine, Centre Hospitalier Universitaire, Toulouse, France.
Abstract
BACKGROUND: Some case reports have described parkinsonism with amiodarone. We investigated a putative association between parkinsonism and exposure to amiodarone. METHODS: We used the WHO pharmacovigilance database (VigiBase® ). All adverse drug reactions with 'Parkinson-like events' and amiodarone were included. Four disproportionality analyses were performed: 1/after inclusion of all reports, 2/according to sex, 3/for the twenty last years (2000-2019), and 4/after exclusion of concomitant drugs known to induce parkinsonism (antipsychotic, antivertigo, antiemetic antinauseant drugs, flunarizine). Results are expressed as reporting odds ratios (ROR; 95% CI) and information component (IC). RESULTS: No significant association was found in the whole population [ROR = 0.83 (0.65-1.06), IC = -0.7 (IC025 = -0.65)], in men, in women, for the 2000-2019 years, or after exclusion of drugs inducing parkinsonism. CONCLUSION: We failed to find any signal of parkinsonism with amiodarone. We suggest that reports of parkinsonism with amiodarone could be mainly explained by other underlying causes.
BACKGROUND: Some case reports have described parkinsonism with amiodarone. We investigated a putative association between parkinsonism and exposure to amiodarone. METHODS: We used the WHO pharmacovigilance database (VigiBase® ). All adverse drug reactions with 'Parkinson-like events' and amiodarone were included. Four disproportionality analyses were performed: 1/after inclusion of all reports, 2/according to sex, 3/for the twenty last years (2000-2019), and 4/after exclusion of concomitant drugs known to induce parkinsonism (antipsychotic, antivertigo, antiemetic antinauseant drugs, flunarizine). Results are expressed as reporting odds ratios (ROR; 95% CI) and information component (IC). RESULTS: No significant association was found in the whole population [ROR = 0.83 (0.65-1.06), IC = -0.7 (IC025 = -0.65)], in men, in women, for the 2000-2019 years, or after exclusion of drugs inducing parkinsonism. CONCLUSION: We failed to find any signal of parkinsonism with amiodarone. We suggest that reports of parkinsonism with amiodarone could be mainly explained by other underlying causes.