Literature DB >> 33098093

Pituitary incidentalomas in paediatric population: Incidence and characteristics.

Muhammed Shareef1, Mona P Nasrallah2, Natally AlArab1, Lamya A Atweh1, Catherina Zadeh1, Roula Hourani1.   

Abstract

OBJECTIVE: To determine the incidence of pituitary incidentalomas in the paediatric population and among its different age subgroups as well as to identify the characteristics of these lesions. Additionally, we aim to give a perspective on the management and follow-up of these patients. DESIGN AND PATIENTS: We retrospectively studied MRI of children aged 18 years or below who underwent MRI with sellar region within their field of view between January 2010 and December 2018. MEASUREMENTS: Pituitary lesions were considered incidental according to the definition by the Endocrine Society. We reported the size, location and signal characteristics of each lesion. Medical charts of the subjects were reviewed for age, sex, the MRI indication and the hormonal assays levels.
RESULTS: We identified 40 pituitary lesions of which 31 were incidental lesions. The incidence of pituitary incidentaloma in our cohort was 22 per 1000 patients with female predisposition ( 64.5%) and a mean age of 11 ± 6 years. Rathke's cleft cyst was the most prevalent lesion, accounting for 67.7% followed by cystic pituitary lesions and microadenomas. The most common indications for imaging were growth disturbance (12.9%) followed by headache (9.7%). Abnormal laboratory workup was present in 13% of the subjects. Incidental lesions were more common in the older age groups compared to young children.
CONCLUSION: Incidental pituitary lesions in the paediatric population are relatively infrequent and increases with age. Rathke's cleft cyst is the most common incidentally encountered pituitary lesion followed by cystic pituitary lesions and microadenomas.
© 2020 John Wiley & Sons Ltd.

Entities:  

Year:  2020        PMID: 33098093     DOI: 10.1111/cen.14353

Source DB:  PubMed          Journal:  Clin Endocrinol (Oxf)        ISSN: 0300-0664            Impact factor:   3.478


  2 in total

Review 1.  Dealing With Brain MRI Findings in Pediatric Patients With Endocrinological Conditions: Less Is More?

Authors:  Francesco Baldo; Maura Marin; Flora Maria Murru; Egidio Barbi; Gianluca Tornese
Journal:  Front Endocrinol (Lausanne)       Date:  2022-01-12       Impact factor: 5.555

2.  The clinical course of Rathke's cleft cysts in pediatric patients: impact on growth and pubertal development.

Authors:  Yousuke Higuchi; Kosei Hasegawa; Toshihide Kubo; Hiroyuki Tanaka; Hirokazu Tsukahara
Journal:  Clin Pediatr Endocrinol       Date:  2021-11-01
  2 in total

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