Nengzhi Jiang1, Jiahua Xu2, Xinying Li3, Yanyu Wang4, Liping Zhuang2, Shaozheng Qin5. 1. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; School of Psychology, Weifang Medical University, Weifang, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. 2. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China; Chinese Institute for Brain Research, Beijing, China. 3. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address: lixy@psych.ac.cn. 4. School of Psychology, Weifang Medical University, Weifang, China. 5. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing, China; Chinese Institute for Brain Research, Beijing, China. Electronic address: szqin@bnu.edu.cn.
Abstract
BACKGROUND: The synergic interaction of risk genes and environmental factors has been thought to play a critical role in mediating emotion-related brain circuitry function and dysfunction in depression and anxiety disorders. Little, however, is known regarding neurodevelopmental bases underlying how maternal negative parenting affects emotion-related brain circuitry linking to adolescent internalizing symptoms and whether this neurobehavioral association is heritable during adolescence. METHODS: The effects of maternal parenting on amygdala-based emotional circuitry and internalizing symptoms were examined by using longitudinal functional magnetic resonance imaging among 100 monozygotic twins and 78 dizygotic twins from early adolescence (age 13 years) to mid-adolescence (age 16 years). The mediation effects among variables of interest and their heritability were assessed by structural equation modeling and quantitative genetic analysis, respectively. RESULTS: Exposure to maternal negative parenting was positively predictive of stronger functional connectivity of the amygdala with the ventrolateral prefrontal cortex. This neural pathway mediated the association between negative parenting and adolescent depressive symptoms and exhibited moderate heritability (21%). CONCLUSIONS: These findings highlight that maternal negative parenting in early adolescence is associated with the development of atypical amygdala-prefrontal connectivity in relation to internalizing depressive symptoms in mid-adolescence. Such abnormality of emotion-related brain circuitry is heritable to a moderate degree.
BACKGROUND: The synergic interaction of risk genes and environmental factors has been thought to play a critical role in mediating emotion-related brain circuitry function and dysfunction in depression and anxiety disorders. Little, however, is known regarding neurodevelopmental bases underlying how maternal negative parenting affects emotion-related brain circuitry linking to adolescent internalizing symptoms and whether this neurobehavioral association is heritable during adolescence. METHODS: The effects of maternal parenting on amygdala-based emotional circuitry and internalizing symptoms were examined by using longitudinal functional magnetic resonance imaging among 100 monozygotic twins and 78 dizygotic twins from early adolescence (age 13 years) to mid-adolescence (age 16 years). The mediation effects among variables of interest and their heritability were assessed by structural equation modeling and quantitative genetic analysis, respectively. RESULTS: Exposure to maternal negative parenting was positively predictive of stronger functional connectivity of the amygdala with the ventrolateral prefrontal cortex. This neural pathway mediated the association between negative parenting and adolescent depressive symptoms and exhibited moderate heritability (21%). CONCLUSIONS: These findings highlight that maternal negative parenting in early adolescence is associated with the development of atypical amygdala-prefrontal connectivity in relation to internalizing depressive symptoms in mid-adolescence. Such abnormality of emotion-related brain circuitry is heritable to a moderate degree.
Authors: Adina S Fischer; Bailey Holt-Gosselin; Kelsey E Hagan; Scott L Fleming; Akua F Nimarko; Ian H Gotlib; Manpreet K Singh Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2022-03-08
Authors: Elena Pozzi; Nandita Vijayakumar; Michelle L Byrne; Katherine O Bray; Marc Seal; Sally Richmond; Andrew Zalesky; Sarah L Whittle Journal: Dev Cogn Neurosci Date: 2021-03-22 Impact factor: 6.464