Literature DB >> 3309645

Induction of the SOS response by hydroxyurea in Escherichia coli K12.

J Barbé1, A Villaverde, R Guerrero.   

Abstract

Hydroxyurea at concentrations higher than 10(-2) M induced the recA and sfiA genes of E. coli as well as the lambda prophage by a pathway independent of the recBC genes. In addition, the hydroxyurea-mediated induction of the SOS response is accompanied by a recA-dependent decrease on the cellular ATP pool. The presence of the multicopy plasmid pPS2, harboring the nrdAB genes (encoding the ribonucleoside reductase enzyme), abolished the hydroxyurea-induced expression of the recA gene. These data lead us to suggest that induction of the SOS response by hydroxyurea is due to the blocking of DNA replication by the inhibition of the ribonucleoside reductase complex activity.

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Year:  1987        PMID： 3309645     DOI： 10.1016/0165-7992(87)90105-9

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  10 in total

1.  Measurement of in vivo expression of nrdA and nrdB genes of Escherichia coli by using lacZ gene fusions.

Authors:  I Gibert; S Calero; J Barbé
Journal:  Mol Gen Genet       Date:  1990-02

2.  Replication Rapidly Recovers and Continues in the Presence of Hydroxyurea in Escherichia coli.

Authors:  Samvel A Nazaretyan; Neda Savic; Michael Sadek; Brandy J Hackert; Justin Courcelle; Charmain T Courcelle
Journal:  J Bacteriol       Date:  2018-02-23       Impact factor: 3.490

3.  The SOS Regulatory Network.

Authors:  Lyle A Simmons; James J Foti; Susan E Cohen; Graham C Walker
Journal:  EcoSal Plus       Date:  2008-07-25

4.  Smc5/6 Complex Promotes Rad3ATR Checkpoint Signaling at the Perturbed Replication Fork through Sumoylation of the RecQ Helicase Rqh1.

Authors:  Saman Khan; Nafees Ahamad; Sankhadip Bhadra; Zheng Xu; Yong-Jie Xu
Journal:  Mol Cell Biol       Date:  2022-05-25       Impact factor: 5.069

5.  Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli.

Authors:  Bryan W Davies; Michael A Kohanski; Lyle A Simmons; Jonathan A Winkler; James J Collins; Graham C Walker
Journal:  Mol Cell       Date:  2009-12-11       Impact factor: 17.970

6.  The tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli.

Authors:  Toru Nakayashiki; Natsumi Saito; Rikiya Takeuchi; Hiroshi Kadokura; Kenji Nakahigashi; Barry L Wanner; Hirotada Mori
Journal:  J Bacteriol       Date:  2013-03-01       Impact factor: 3.490

7.  DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics.

Authors:  Timothy J Opperman; Steven M Kwasny; Jessica Bo Li; Mark A Lewis; Daniel Aiello; John D Williams; Norton P Peet; Donald T Moir; Terry L Bowlin; Eric C Long
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

Review 8.  Checkpoint functions of RecQ helicases at perturbed DNA replication fork.

Authors:  Nafees Ahamad; Saman Khan; Alaa Taha A Mahdi; Yong-Jie Xu
Journal:  Curr Genet       Date:  2021-01-11       Impact factor: 3.886

9.  Genome-Wide Identification and Expression Analysis of SOS Response Genes in Salmonella enterica Serovar Typhimurium.

Authors:  Angela Mérida-Floriano; Will P M Rowe; Josep Casadesús
Journal:  Cells       Date:  2021-04-19       Impact factor: 6.600

10.  Hydroxyurea Induces a Stress Response That Alters DNA Replication and Nucleotide Metabolism in Bacillus subtilis.

Authors:  Katherine J Wozniak; Lyle A Simmons
Journal:  J Bacteriol       Date:  2021-07-08       Impact factor: 3.490
  10 in total

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