Cognitive Dysfunction and Neurophysiologic Mechanism of Breast Cancer Patients Undergoing Chemotherapy Based on Resting State Functional Magnetic Resonance Imaging.

We studied chemotherapy-related cognitive impairment via resting state (RS)-functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in 19 cases of patients with early breast cancer. White matter neuropsychological test treatment were carried out before and after chemotherapy, RS-fMRI, and DTI evaluation. In RS-fMRI with regional homogeneity (ReHo) reflects brain activity. In the DTI with fractional anisotropy (FA) reflect the integrity of the white matter. Determining the region of interest by image analysis, we calculated the neuropsychologic test score using the paired t-test and FA change ReHo values of regions of interest. Finally after the test treatment, in the chemotherapy group for pairing correlation analysis t-test scores change in meaningful inspection and change ReHo and FA. Chemotherapy after chemotherapy than before chemotherapy difference memory test and self-evaluation of cognitive (P < 0.05). ReHo value increases occurred in the right orbitofrontal region and the left dorsolateral prefrontal cortex. Declines in brain regions were the anterior inferior cerebellar lobe, cerebellar lobe, right middle temporal gyrus and the superior temporal gyrus, the lower right of the center area, and the central gyrus. This prospective study on resting state and RS-fMRI functional magnetic resonance DTI study DTI sequence combination chemotherapy for breast cancer-related cognitive disorders supports the "chemo brain" point of view. Chemotherapy can cause memory decline, accompanied by a partial area of the brain and white matter integrity in brain activity changes. Prompt clinical treatment RS-fMRI and DTI have potential applications in assessing chemotherapy-related cognitive impairment.