Literature DB >> 33094349

Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.

Harish N Vasudevan1,2, Calixto-Hope G Lucas3, Javier E Villanueva-Meyer4, Philip V Theodosopoulos2, David R Raleigh1,2.   

Abstract

In this review, we describe Schwann cell development from embryonic neural crest cells to terminally differentiated myelinated and nonmyelinated mature Schwann cells. We focus on the genetic drivers and signaling mechanisms mediating decisions to proliferate versus differentiate during Schwann cell development, highlighting pathways that overlap with Schwann cell development and are dysregulated in tumorigenesis. We conclude by considering how our knowledge of the events underlying Schwann cell development and mouse models of schwannoma, neurofibroma, and malignant peripheral nerve sheath tumor can inform novel therapeutic strategies for patients with cancers derived from Schwann cell lineages. Published by Oxford University Press on behalf of Congress of Neurological Surgeons 2020.

Entities:  

Keywords:  Malignant peripheral nerve sheath tumor; NF1; NF2; Neural crest; Neurofibroma; Schwann cell; Schwannoma

Mesh：

Year:  2021        PMID： 33094349      PMCID： PMC7919339          DOI： 10.1093/neuros/nyaa455

Source DB:  PubMed          Journal:  Neurosurgery        ISSN： 0148-396X            Impact factor:   4.654


  101 in total

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3.  Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

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Journal:  Genes Dev       Date:  2000-07-01       Impact factor: 11.361

Review 4.  Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.

Authors:  Lin Mei; Wen-Cheng Xiong
Journal:  Nat Rev Neurosci       Date:  2008-05-14       Impact factor: 34.870

5.  Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.

Authors:  T Jacks; T S Shih; E M Schmitt; R T Bronson; A Bernards; R A Weinberg
Journal:  Nat Genet       Date:  1994-07       Impact factor: 38.330

6.  Diagnostic utility of SOX10 to distinguish malignant peripheral nerve sheath tumor from synovial sarcoma, including intraneural synovial sarcoma.

Authors:  Yuna Kang; Melike Pekmezci; Andrew L Folpe; Ayca Ersen; Andrew E Horvai
Journal:  Mod Pathol       Date:  2013-08-09       Impact factor: 7.842

Review 7.  Malignant peripheral nerve sheath tumors.

Authors:  Mohamad Farid; Elizabeth G Demicco; Roberto Garcia; Linda Ahn; Pamela R Merola; Angela Cioffi; Robert G Maki
Journal:  Oncologist       Date:  2014-01-27

8.  Expression of glial fibrillary acidic protein (GFAP) in peripheral nerve sheath tumors. A comparative study of immunoreactivity of GFAP, vimentin, S-100 protein, and neurofilament in 38 schwannomas and 18 neurofibromas.

Authors:  E Kawahara; Y Oda; A Ooi; S Katsuda; I Nakanishi; S Umeda
Journal:  Am J Surg Pathol       Date:  1988-02       Impact factor: 6.394

Review 9.  The repair Schwann cell and its function in regenerating nerves.

Authors:  K R Jessen; R Mirsky
Journal:  J Physiol       Date:  2016-03-21       Impact factor: 5.182

10.  Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination.

Authors:  Lai Man Natalie Wu; Jincheng Wang; Andrea Conidi; Chuntao Zhao; Haibo Wang; Zachary Ford; Liguo Zhang; Christiane Zweier; Brian G Ayee; Patrice Maurel; An Zwijsen; Jonah R Chan; Michael P Jankowski; Danny Huylebroeck; Q Richard Lu
Journal:  Nat Neurosci       Date:  2016-06-13       Impact factor: 24.884
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  1 in total

1.  Commentary: Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.

Authors:  Aria M Jamshidi; Anthony Diaz; S Shelby Burks; Allan D Levi
Journal:  Neurosurgery       Date:  2021-01-13       Impact factor: 4.654
  1 in total

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