| Literature DB >> 3309317 |
R M Riggs1, A T McKenzie, S R Byrn, D E Nichols, M M Foreman, L L Truex.
Abstract
beta-Methyldopamine and its enantiomers and racemic beta-phenyldopamine were synthesized and evaluated for dopamine D-1 agonist activity. In the dopamine-sensitive adenylate cyclase assay, beta-phenyldopamine had about one-sixth the activity of dopamine. Racemic beta-methyldopamine was less potent. The absolute configuration of beta-methyldopamine was determined to be R-(+) and S-(-). Evaluation of (R)-(+)- and (S)-(-)-beta-methyldopamine revealed no enantioselectivity for stimulation of adenylate cyclase.Entities:
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Year: 1987 PMID： 3309317 DOI： 10.1021/jm00393a039
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446