Literature DB >> 33092656

Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Kareen Heinze1, Helen C Barron2, Emma K Howes3, Mani Ramaswami4, Matthew R Broome1.   

Abstract

In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.

Entities:  

Keywords:  E/I balance; GABA; autism spectrum disorders; schizophrenia; transdiagnostic

Mesh：

Substances：

Year:  2021        PMID： 33092656      PMCID： PMC7612604          DOI： 10.1192/bjp.2020.163

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  5 in total

1.  Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks.

Authors:  T P Vogels; H Sprekeler; F Zenke; C Clopath; W Gerstner
Journal:  Science       Date:  2011-11-10       Impact factor: 47.728

2.  Schizophrenia and autism-related disorders.

Authors:  Rebecca E Hommer; Susan E Swedo
Journal:  Schizophr Bull       Date:  2015-01-29       Impact factor: 9.306

Review 3.  Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders.

Authors:  Jennifer H Foss-Feig; Brendan D Adkinson; Jie Lisa Ji; Genevieve Yang; Vinod H Srihari; James C McPartland; John H Krystal; John D Murray; Alan Anticevic
Journal:  Biol Psychiatry       Date:  2017-03-14       Impact factor: 13.382

Review 4.  Inhibitory engrams in perception and memory.

Authors:  Helen C Barron; Tim P Vogels; Timothy E Behrens; Mani Ramaswami
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-13       Impact factor: 11.205

5.  The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference.

Authors:  Renée S Koolschijn; Uzay E Emir; Alexandros C Pantelides; Hamed Nili; Timothy E J Behrens; Helen C Barron
Journal:  Neuron       Date:  2018-12-20       Impact factor: 17.173
  5 in total
  1 in total

1.  Loss of the Schizophrenia-linked Furin protein from Drosophila mushroom body neurons results in antipsychotic-reversible habituation deficits.

Authors:  Kyriaki Foka; Eirini-Maria Georganta; Ourania Semelidou; Efthimios M C Skoulakis
Journal:  J Neurosci       Date:  2022-08-25       Impact factor: 6.709
  1 in total

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