| Literature DB >> 33091423 |
Yanyan Xing1, Haley R Steele1, Henry B Hilley1, Yuyan Zhu1, Katy Lawson1, Taylor Niehoff1, Liang Han2.
Abstract
Diverse sensory neurons exhibit distinct neuronal morphologies with a variety of axon terminal arborizations subserving their functions. Because of its clinical significance, the molecular and cellular mechanisms of itch are being intensely studied. However, a complete analysis of itch-sensing terminal arborization is missing. Using an MrgprC11CreERT2 transgenic mouse line, we labeled a small subset of itch-sensing neurons that express multiple itch-related molecules including MrgprA3, MrgprC11, histamine receptor H1, IL-31 receptor, 5-hydroxytryptamine receptor 1F, natriuretic precursor peptide B, and neuromedin B. By combining sparse genetic labeling and whole-mount placental alkaline phosphatase histochemistry, we found that itch-sensing skin arbors exhibit free endings with extensive axonal branching in the superficial epidermis and large receptive fields. These results revealed the unique morphological characteristics of itch-sensing neurons and provide intriguing insights into the basic mechanisms of itch transmission.Entities:
Mesh：
Substances：
Year: 2020 PMID： 33091423 PMCID： PMC8055730 DOI： 10.1016/j.jid.2020.08.030
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551