Philip Pizzo1,2, Norman D Rosenblum3,4,5. 1. Departments of Pediatrics, Microbiology, and Immunology, Stanford University School of Medicine, Stanford, CA, USA. ppizzo@stanford.edu. 2. Stanford Distinguished Careers Institute, Stanford, CA, USA. ppizzo@stanford.edu. 3. The Hospital for Sick Children, Toronto, ON, Canada. 4. Departments of Paediatrics, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. 5. Institute of Nutrition, Metabolism and Diabetes (INMD), Canadian Institutes of Health Research, Ottawa, ON, Canada.