Fernando de Amorim Fernandes1, Amalia Peix2, Raffaele Giubbini3, Ganesan Karthikeyan4, Teresa Massardo5, Chetan Patel4, Luz M Pabon6, Amelia Jimenez-Heffernan7, Erick Alexanderson8, Sadaf Butt9, Alka Kumar10, Victor Marin11, Olga Morozova12, Diana Paez12, Claudio T Mesquita13, Ernest V Garcia14. 1. Nuclear Medicine Department, Hospital Universitario Antonio Pedro-EBSERH-UFF, 303 Marquês de Parana street, Niterói, Rio de Janeiro, 24033-900, Brazil. fernando.fernandes2@gmail.com. 2. Nuclear Medicine Department, Institute of Cardiology, La Habana, Cuba. 3. Nuclear Medicine, Spedali Civili, Brescia, Italy. 4. All India Institute of Medical Sciences, New Delhi, India. 5. Hospital Clinico Universidad de Chile, Santiago, Chile. 6. Fundacion Valle del Lili, Cali, Colombia. 7. Hospital Juan Ramon Jimenez, Huelva, Spain. 8. Instituto Nacional de Cardiologia Ignacio Chavez, Mexico, DF, Mexico. 9. Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan. 10. Dr. B L Kapur Memorial Hospital, New Delhi, India. 11. Fundacion Cardioinfantil, Bogota, Colombia. 12. Nuclear Medicine and Diagnostic Imaging Section, International Atomic Energy Agency, Vienna, Austria. 13. Nuclear Medicine Department, Hospital Universitario Antonio Pedro-EBSERH-UFF, 303 Marquês de Parana street, Niterói, Rio de Janeiro, 24033-900, Brazil. 14. Emory University, Atlanta, GA, USA.
Abstract
BACKGROUND: Gated myocardial perfusion scintigraphy (GMPS) phase analysis is an important tool to investigate the physiology of left ventricular (LV) dyssynchrony. We aimed to test the performance of GMPS LV function and phase analysis in different clinical settings and on a diverse population. METHODS: This is a post hoc analysis of a prospective, non-randomized, multinational, multicenter cohort study. Clinical evaluation and GMPS prior to cardiac resynchronization therapy (CRT)(baseline) and 6-month post CRT (follow-up) were done. LV end-systolic volume (LVESV), LV end-diastolic volume (LVEDV), LV ejection fraction (LVEF), LV phase standard deviation (LVPSD), and percentage of left ventricle non-viable (PLVNV) were obtained by 10 centers and compared to the core lab. RESULTS: 276 GMPS studies had all data available from individual sites and from core lab. There were no statistically significant differences between all variables except for LVPSD. When subjects with no mechanical dyssynchrony were excluded, LVPSD difference became non-significant. LVESV, LVEF, LVPSD and PLVNV had strong correlation in site against core lab comparison. Bland-Altman plots demonstrated good agreement. CONCLUSIONS: The presented correlation and agreement of LV function and dyssynchrony analysis over different sites with a diverse sample corroborate the strength of GMPS in the management of heart failure in clinical practice.
BACKGROUND: Gated myocardial perfusion scintigraphy (GMPS) phase analysis is an important tool to investigate the physiology of left ventricular (LV) dyssynchrony. We aimed to test the performance of GMPS LV function and phase analysis in different clinical settings and on a diverse population. METHODS: This is a post hoc analysis of a prospective, non-randomized, multinational, multicenter cohort study. Clinical evaluation and GMPS prior to cardiac resynchronization therapy (CRT)(baseline) and 6-month post CRT (follow-up) were done. LV end-systolic volume (LVESV), LV end-diastolic volume (LVEDV), LV ejection fraction (LVEF), LV phase standard deviation (LVPSD), and percentage of left ventricle non-viable (PLVNV) were obtained by 10 centers and compared to the core lab. RESULTS: 276 GMPS studies had all data available from individual sites and from core lab. There were no statistically significant differences between all variables except for LVPSD. When subjects with no mechanical dyssynchrony were excluded, LVPSD difference became non-significant. LVESV, LVEF, LVPSD and PLVNV had strong correlation in site against core lab comparison. Bland-Altman plots demonstrated good agreement. CONCLUSIONS: The presented correlation and agreement of LV function and dyssynchrony analysis over different sites with a diverse sample corroborate the strength of GMPS in the management of heart failure in clinical practice.