Stefano Lai1, Peter Lingström2, Maria Grazia Cagetti3, Fabio Cocco4, Gianfranco Meloni5, Maria Antonietta Arrica5, Guglielmo Campus5,6,7,8,9. 1. Department of Biomedical Sciences-Medical School, University of Sassari, Sassari, Italy. 2. Department of Cariology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 3. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. 4. Department of Surgery, Medical and Experimental Sciences, University of Sassari, Sassari, Italy. fcocco@uniss.it. 5. Department of Surgery, Medical and Experimental Sciences, University of Sassari, Sassari, Italy. 6. Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland. 7. Präventivzahnmedizin und orale Epidemiologie der Lutz Zürrer Stiftung, Klinik für Zahnerhaltung, Präventiv- und Kinderzahnmedizin, Zahnmedizinische Kliniken (ZMK), Universitär Bern, Freiburgstrasse 7, 3010, Bern, Switzerland. 8. Department of Surgery, Microsurgery and Medicine Sciences, School of Dentistry, University of Sassari, Sassari, Italy. 9. WHO Collaborating Centre for Epidemiology and Community Dentistry, University of Milan, Milan, Italy.
Abstract
OBJECTIVE: The short-term effect (60 days) of Lactobacillus brevis CD2 lozenges vs placebo on variables related to caries and gingivitis in type 1 diabetic children was evaluated. MATERIAL AND METHODS:Eight diabetics (4-14 years old) were assigned to two groups (n = 34 subjects each), probiotic lozenges and placebo. Stimulated saliva for microbiological analysis and plaque pH were assessed at baseline (t0), 30 days (t1), 60 days (t2) and in the follow-up period (90 days from baseline, t3). Gingival status was assessed at t0, t2 and t3. Two-way ANOVA assessed differences between groups. RESULTS: In the probiotic group, Streptococcus mutans bacterial density mean scores dropped from 3.11 ± 1.13 at baseline to 1.82 ± 0.72 (t2) and to 2.06 ± 0.56 (t3), while in the placebo group, the scores were 3.09 ± 0.8 (t0), 2.82 ± 0.47 (t2) and 3.11 ± 0.43 (t3) (p < 0.01). Lowest and maximum pH fall increased in the probiotic group, from 5.37 ± 0.41 at baseline to 5.49 ± 0.24 at t3 (p < 0.01) and from 1.20 ± 0.46 to 0.98 ± 0.29 (p = 0.02). Bleeding score decreased significantly in both groups, showing a statistically significant lower bleeding score at t2 in the probiotic group (25.6%, 95% CI 21.5-32.7 vs 29.5%, 95% CI 25.2-34.9, p = 0.02). CONCLUSIONS:Lactobacillus brevis CD2 has shown to improve caries-related risk factors and gingival health in diabetic children. CLINICAL RELEVANCE: Lactobacillus brevis CD2 might contribute to improved oral health in type 1 diabetic children.
RCT Entities:
OBJECTIVE: The short-term effect (60 days) of Lactobacillus brevisCD2 lozenges vs placebo on variables related to caries and gingivitis in type 1 diabeticchildren was evaluated. MATERIAL AND METHODS: Eight diabetics (4-14 years old) were assigned to two groups (n = 34 subjects each), probiotic lozenges and placebo. Stimulated saliva for microbiological analysis and plaque pH were assessed at baseline (t0), 30 days (t1), 60 days (t2) and in the follow-up period (90 days from baseline, t3). Gingival status was assessed at t0, t2 and t3. Two-way ANOVA assessed differences between groups. RESULTS: In the probiotic group, Streptococcus mutans bacterial density mean scores dropped from 3.11 ± 1.13 at baseline to 1.82 ± 0.72 (t2) and to 2.06 ± 0.56 (t3), while in the placebo group, the scores were 3.09 ± 0.8 (t0), 2.82 ± 0.47 (t2) and 3.11 ± 0.43 (t3) (p < 0.01). Lowest and maximum pH fall increased in the probiotic group, from 5.37 ± 0.41 at baseline to 5.49 ± 0.24 at t3 (p < 0.01) and from 1.20 ± 0.46 to 0.98 ± 0.29 (p = 0.02). Bleeding score decreased significantly in both groups, showing a statistically significant lower bleeding score at t2 in the probiotic group (25.6%, 95% CI 21.5-32.7 vs 29.5%, 95% CI 25.2-34.9, p = 0.02). CONCLUSIONS:Lactobacillus brevisCD2 has shown to improve caries-related risk factors and gingival health in diabeticchildren. CLINICAL RELEVANCE: Lactobacillus brevisCD2 might contribute to improved oral health in type 1 diabeticchildren.
Authors: M P Angarita-Díaz; D Forero-Escobar; X A Cerón-Bastidas; C A Cisneros-Hidalgo; F Dávila-Narvaez; C M Bedoya-Correa; Sidonio C Freitas; C L Cabrera-Arango; R Melo-Colina Journal: Eur Arch Paediatr Dent Date: 2019-08-06
Authors: Maria D Ferrer; Arantxa López-López; Teodora Nicolescu; Ariana Salavert; Iago Méndez; Jordi Cuñé; Carmen Llena; Alex Mira Journal: Odontology Date: 2019-09-17 Impact factor: 2.634