A robust electrochemical sensing based on bimetallic metal-organic framework mediated Mo2C for simultaneous determination of acetaminophen and isoniazid.

Herein, a Mo2C/bimetallic zeolitic imidazolate framework-modified glassy carbon electrode (Mo2C@BMZIFs/GCE) was established as an electrochemical sensor for the simultaneous sensitive determination of acetaminophen (APAP) and isoniazid (INZ). The apparent morphology, structural composition, and electrochemical properties were comprehensively investigated. The outstanding electrocatalytic activity and conductivity endow the sensor desirable electrochemical performance toward APAP and INZ compared to the bare GCE, such as wide linear range, low detection limit, and high selectivity. Under the optimum conditions, a linear relationship between the oxidation peak current and the concentration of the measured object was obtained, with linear ranges from 0.1 to 300 μM for APAP and from 10 to 3500 μM for INZ. The detection limits for APAP and INZ were 0.03 μM and 1.5 μM, respectively. More importantly, the APAP and INZ oxidation peaks could be completely separated. Moreover, the highly sensitive and stable sensor was applied to detect APAP and INZ in human serum. This work can provide a viable route to rational design and construct electrochemical sensors for drug monitoring and clinical diagnosis.