Literature DB >> 330809

The mechanism of action of nitro-heterocyclic antimicrobial drugs. Primary target of 1-methyl-2-nitro-5-vinylimidazole is DNA.

B P Goldstein, E Nielsen, M Berti, G Bolzoni, L G Silvestri.   

Abstract

The antimicrobial drug 1-methyl-2-nitro-5-vinylimidazole (MEV) preferentially blocked DNA synthesis, was mutagenic and induced coliphage lambda in Escherichia coli. The antibacterial effects of MEV are the consequences of repairable damage to DNA, as shown by hypersensitivity of recA and uvr strains to MEV and related drugs, stimulation by MEV of DNA turnover which was dependent on the product of the uvrA gene, and the presence of cross-links in DNA from MEV-treated bacteria.

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Year:  1977        PMID： 330809     DOI： 10.1099/00221287-100-2-271

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  4 in total

1.  Interaction of metronidazole with DNA repair mutants of Escherichia coli.

Authors:  T C Yeung; B B Beaulieu; M A McLafferty; P Goldman
Journal:  Antimicrob Agents Chemother       Date:  1984-01       Impact factor: 5.191

2.  New medium for isolation of Actinomyces viscosus and Actinomyces naeslundii from dental plaque.

Authors:  K S Kornman; W J Loesche
Journal:  J Clin Microbiol       Date:  1978-06       Impact factor: 5.948

3.  The DNA repair host-mediated assay as a rapid and sensitive in vivo procedure for the determination of genotoxic factors present in various organs of mice. Some preliminary results with mitomycin C.

Authors:  G R Mohn
Journal:  Arch Toxicol       Date:  1984-10       Impact factor: 5.153

4.  Effects of antibiotics on bacterial species composition and metabolic activities in chemostats containing defined populations of human gut microorganisms.

Authors:  Dorothy F Newton; Sandra Macfarlane; George T Macfarlane
Journal:  Antimicrob Agents Chemother       Date:  2013-02-12       Impact factor: 5.191
  4 in total

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