Wenjie Zhang1, Yu Su2, Lei Liu3, Huiru Zhao2, Meng Wen2, Yujing Zhao2, Shan Lu2, Yuying Chen1, Xiangyu Cao1, Jun Wu4. 1. Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine, Beijing, China. 2. Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, China. 3. Department of Clinical Laboratory, Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology, Hubei, China. 4. Department of Laboratory Medicine, Peking University Fourth School of Clinical Medicine, Beijing, China; Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, China. Electronic address: wujunpostbox@sina.com.
Abstract
BACKGROUND: Deep vein thrombosis (DVT) is a common complication in patients with traumatic injury. The purpose of this study was to develop a potential predictor of DVT. METHODS: This case-control study enrolled adult trauma patients and healthy volunteers. Patients underwent angiography before surgery to diagnose DVT. Patients with or without DVT were matched by gender, age and fracture sites. Laboratory parameters included lysis potential (LP), lysis time (LT), blood cell counts, conventional coagulation tests, tissue plasminogen activator inhibitor complex (tPAIC) and others. RESULTS: 41 of 319 patients with DVT were matched with 41 patients without DVT and 80 healthy volunteers were controls. LP and LT were significantly decreased in patients with DVT than without (P = 0.043 and P = 0.014, respectively). The level of tPAIC in the DVT group was significantly higher than in patients without DVT (P = 0.042). We defined the Fibrinolysis Index as (-10.707) × LP + (-0.607) × LT (min) + 0.012 × fibrinogen (mg/dl) + 0.299 × tPAIC (ng/ml) + 9.917, and found that the area under the receiver operating characteristic curve for the Fibrinolysis Index was 0.802, making it a novel indicator. CONCLUSION: The Fibrinolysis Index represents a new discriminator for predicting DVT after traumatic lower extremity fractures.
BACKGROUND:Deep vein thrombosis (DVT) is a common complication in patients with traumatic injury. The purpose of this study was to develop a potential predictor of DVT. METHODS: This case-control study enrolled adult traumapatients and healthy volunteers. Patients underwent angiography before surgery to diagnose DVT. Patients with or without DVT were matched by gender, age and fracture sites. Laboratory parameters included lysis potential (LP), lysis time (LT), blood cell counts, conventional coagulation tests, tissue plasminogen activator inhibitor complex (tPAIC) and others. RESULTS: 41 of 319 patients with DVT were matched with 41 patients without DVT and 80 healthy volunteers were controls. LP and LT were significantly decreased in patients with DVT than without (P = 0.043 and P = 0.014, respectively). The level of tPAIC in the DVT group was significantly higher than in patients without DVT (P = 0.042). We defined the Fibrinolysis Index as (-10.707) × LP + (-0.607) × LT (min) + 0.012 × fibrinogen (mg/dl) + 0.299 × tPAIC (ng/ml) + 9.917, and found that the area under the receiver operating characteristic curve for the Fibrinolysis Index was 0.802, making it a novel indicator. CONCLUSION: The Fibrinolysis Index represents a new discriminator for predicting DVT after traumatic lower extremity fractures.