Michael Dougan1, Yinghong Wang2, Alberto Rubio-Tapia3, Joseph K Lim4. 1. Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: mldougan@partners.org. 2. Division of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas. 3. Division of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio. 4. Yale Liver Center and Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut.
Abstract
BACKGROUND & AIMS: Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for oncology, leading to durable remissions in a subset of patients, but also a broad range of potentially life-threatening inflammatory toxicities, many of which involve the gastrointestinal (GI) tract and liver. The purpose of this expert review was to update gastroenterologists on the gastrointestinal and hepatic toxicities of ICIs and provide best practice advice on their diagnosis and management. METHODS: The evidence reviewed in this work combines the expert clinical opinion of the authors with a comprehensive search of several English-language databases and a manual review of relevant publications.
BACKGROUND & AIMS: Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for oncology, leading to durable remissions in a subset of patients, but also a broad range of potentially life-threatening inflammatory toxicities, many of which involve the gastrointestinal (GI) tract and liver. The purpose of this expert review was to update gastroenterologists on the gastrointestinal and hepatic toxicities of ICIs and provide best practice advice on their diagnosis and management. METHODS: The evidence reviewed in this work combines the expert clinical opinion of the authors with a comprehensive search of several English-language databases and a manual review of relevant publications.
Authors: Cynthia Liu; Rajan Amin; Anusha S Thomas; Yinghong Wang; Malek Shatila; Nicholas Short; Mehmet Altan; Amishi Shah; Omar Alhalabi; Pablo Okhuysen Journal: J Cancer Res Clin Oncol Date: 2022-08-28 Impact factor: 4.322
Authors: Bart van Hoek; Ellen Kapiteijn; Maaike Biewenga; Monique K van der Kooij; Michel W J M Wouters; Maureen J B Aarts; Franchette W P J van den Berkmortel; Jan Willem B de Groot; Marye J Boers-Sonderen; Geke A P Hospers; Djura Piersma; Rozemarijn S van Rijn; Karijn P M Suijkerbuijk; Albert J Ten Tije; Astrid A M van der Veldt; Gerard Vreugdenhil; John B A G Haanen; Alfons J M van der Eertwegh Journal: Hepatol Int Date: 2021-02-25 Impact factor: 6.047