| Literature DB >> 33080229 |
Sébastien Tremblay1, Leah Acker2, Arash Afraz3, Daniel L Albaugh4, Hidetoshi Amita5, Ariana R Andrei6, Alessandra Angelucci7, Amir Aschner8, Puiu F Balan9, Michele A Basso10, Giacomo Benvenuti11, Martin O Bohlen12, Michael J Caiola4, Roberto Calcedo13, James Cavanaugh14, Yuzhi Chen11, Spencer Chen11, Mykyta M Chernov15, Andrew M Clark7, Ji Dai16, Samantha R Debes6, Karl Deisseroth17, Robert Desimone2, Valentin Dragoi6, Seth W Egger2, Mark A G Eldridge18, Hala G El-Nahal12, Francesco Fabbrini19, Frederick Federer7, Christopher R Fetsch20, Michal G Fortuna21, Robert M Friedman15, Naotaka Fujii22, Alexander Gail23, Adriana Galvan4, Supriya Ghosh24, Marc Alwin Gieselmann25, Roberto A Gulli26, Okihide Hikosaka5, Eghbal A Hosseini2, Xing Hu4, Janina Hüer21, Ken-Ichi Inoue27, Roger Janz6, Mehrdad Jazayeri2, Rundong Jiang28, Niansheng Ju28, Kohitij Kar2, Carsten Klein29, Adam Kohn30, Misako Komatsu22, Kazutaka Maeda5, Julio C Martinez-Trujillo31, Masayuki Matsumoto32, John H R Maunsell24, Diego Mendoza-Halliday2, Ilya E Monosov33, Ross S Muers25, Lauri Nurminen7, Michael Ortiz-Rios34, Daniel J O'Shea35, Stéphane Palfi36, Christopher I Petkov25, Sorin Pojoga6, Rishi Rajalingham2, Charu Ramakrishnan37, Evan D Remington2, Cambria Revsine38, Anna W Roe39, Philip N Sabes40, Richard C Saunders18, Hansjörg Scherberger23, Michael C Schmid41, Wolfram Schultz42, Eyal Seidemann11, Yann-Suhan Senova36, Michael N Shadlen43, David L Sheinberg44, Caitlin Siu7, Yoland Smith4, Selina S Solomon8, Marc A Sommer12, John L Spudich45, William R Stauffer46, Masahiko Takada47, Shiming Tang28, Alexander Thiele25, Stefan Treue23, Wim Vanduffel48, Rufin Vogels19, Matthew P Whitmire11, Thomas Wichmann4, Robert H Wurtz14, Haoran Xu2, Azadeh Yazdan-Shahmorad49, Krishna V Shenoy50, James J DiCarlo2, Michael L Platt51.
Abstract
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.Entities:
Keywords: Gene therapy; Monkey; Monkeys; Non-human primates; Nonhuman primates; Open Science; Optical control; Optogenetic; Optogenetics; Viral vectors
Mesh：
Year: 2020 PMID： 33080229 PMCID： PMC7962465 DOI： 10.1016/j.neuron.2020.09.027
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 18.688