Mayumi Suzuki1,2, Toshihiro Okamoto3, Yuichi Akagi3, Kentaro Matsui1,4,5,6, Haruki Sekiguchi1,2,7,8, Natsumi Satoya1, Yuji Inoue1, Akihisa Tatsuta1, Nobuhisa Hagiwara2. 1. Division of Comprehensive Sleep Medicine, Tokyo Women's Medical University, Tokyo, Japan. 2. Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan. 3. Department of Oral and Maxillofacial Surgery, Tokyo Women's Medical University, Tokyo, Japan. 4. Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan. 5. Department of Clinical Laboratory, National Institute of Mental Health, National Center of Neurology & Psychiatry, Tokyo, Japan. 6. Department of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology & Psychiatry, Tokyo, Japan. 7. Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Fukakusa, Japan. 8. Clinical Research Institute, National Hospital Organization Yokohama Medical Center, Yokohama, Japan.
Abstract
BACKGROUND: Oral myofunctional therapy (MFT) is an effective treatment for mild-to-moderate obstructive sleep apnoea (OSA) in middle-aged patients. However, few reports have described its use in elderly patients with moderate and severe OSA. Moreover, no studies have examined the relationship between changes in tongue pressure with MFT and the severity of OSA. OBJECTIVE: We conducted an interventional study using MFT to evaluate the effect of MFT on middle-to-senior-aged patients with moderate or severe OSA and compared changes in apnoea-hypopnea index (AHI) and tongue pressure. METHODS: Thirty-two OSA patients (≥45 years) treated with continuous positive airway pressure (CPAP) were included. MFT was performed in parallel with CPAP. Three days after CPAP discontinuation, polysomnographies were performed and tongue pressures were measured before and after MFT. RESULTS: Patients were 69.3 ± 1.5 years old. After 6 months of MFT, AHI decreased significantly from 34.7 to 29.0/h (P = .03), while tongue pressure significantly increased from 35.9 to 45.6 kPa (P < .01). Seven patients (22%), including 6 of the 12 patients with moderate OSA (50%), experienced successful CPAP discontinuation. CONCLUSIONS: MFT can be a useful intervention even among middle-aged to elderly patients with OSA. Increased tongue pressure may have contributed to the AHI improvement. Clinical trials: Trial registration at www.umin.ac.jp UMIN000027547.
BACKGROUND: Oral myofunctional therapy (MFT) is an effective treatment for mild-to-moderate obstructive sleep apnoea (OSA) in middle-aged patients. However, few reports have described its use in elderly patients with moderate and severe OSA. Moreover, no studies have examined the relationship between changes in tongue pressure with MFT and the severity of OSA. OBJECTIVE: We conducted an interventional study using MFT to evaluate the effect of MFT on middle-to-senior-aged patients with moderate or severe OSA and compared changes in apnoea-hypopnea index (AHI) and tongue pressure. METHODS: Thirty-two OSA patients (≥45 years) treated with continuous positive airway pressure (CPAP) were included. MFT was performed in parallel with CPAP. Three days after CPAP discontinuation, polysomnographies were performed and tongue pressures were measured before and after MFT. RESULTS:Patients were 69.3 ± 1.5 years old. After 6 months of MFT, AHI decreased significantly from 34.7 to 29.0/h (P = .03), while tongue pressure significantly increased from 35.9 to 45.6 kPa (P < .01). Seven patients (22%), including 6 of the 12 patients with moderate OSA (50%), experienced successful CPAP discontinuation. CONCLUSIONS: MFT can be a useful intervention even among middle-aged to elderly patients with OSA. Increased tongue pressure may have contributed to the AHI improvement. Clinical trials: Trial registration at www.umin.ac.jp UMIN000027547.
Authors: Laura Rodríguez-Alcalá; Juan Martín-Lagos Martínez; Carlos O Connor-Reina; Guillermo Plaza Journal: PLoS One Date: 2021-02-18 Impact factor: 3.240
Authors: Carlos O'Connor-Reina; Jose María Ignacio Garcia; Laura Rodriguez Alcala; Elisa Rodríguez Ruiz; María Teresa Garcia Iriarte; Juan Carlos Casado Morente; Peter Baptista; Guillermo Plaza Journal: J Clin Med Date: 2021-12-09 Impact factor: 4.241