Literature DB >> 33078220

Multi-year prevalence and macrolide resistance of Mycoplasma genitalium in clinical samples from a southern Italian hospital.

Abbasciano Angela1, Del Prete Raffaele1,2, Romanelli Federica1, Mosca Adriana1,2, Santacroce Luigi1,2, Ronga Luigi3.   

Abstract

The use of azithromycin for the treatment of Mycoplasma genitalium infections has led to resistance to macrolides. From July 2014 to July 2020, 7150 samples were analysed for the detection of sexually transmitted infections at the Policlinico of Bari. A total of 67/7150 samples (0.93%) were positive for MG DNA and 47 samples were analysed for the evaluation of six azithromycin resistance-associated mutations. In 5/47 samples, the A2058G mutation was detected (10.63%). Although the cases of positive MG samples and mutations are low in our reality, diagnostic tests to detect azithromycin resistant-associated genes may provide a convenient way to monitor resistance rate.

Entities:  

Keywords:  Azithromycin resistance; Epidemiology; Multiplex real-time PCR; Mycoplasma genitalium; Surveillance

Year:  2020        PMID： 33078220     DOI： 10.1007/s10096-020-04068-3

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  10 in total

1.  Detection of macrolide resistance in Mycoplasma genitalium in France.

Authors:  Delphine Chrisment; Alain Charron; Charles Cazanave; Sabine Pereyre; Cécile Bébéar
Journal:  J Antimicrob Chemother       Date:  2012-07-06       Impact factor: 5.790

2.  Prevalence of cervical colonization by Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium in childbearing age women by a commercially available multiplex real-time PCR: An Italian observational multicentre study.

Authors:  Christian Leli; Antonella Mencacci; Maria Agnese Latino; Pierangelo Clerici; Mario Rassu; Stefano Perito; Roberto Castronari; Eleonora Pistoni; Eugenio Luciano; Daniela De Maria; Cristina Morazzoni; Michela Pascarella; Silvia Bozza; Alessandra Sensini
Journal:  J Microbiol Immunol Infect       Date:  2017-06-28       Impact factor: 4.399

3.  Distribution of genital Mollicutes in the vaginal ecosystem of women with different clinical conditions.

Authors:  Claudio Foschi; Melissa Salvo; Antonietta D'Antuono; Valeria Gaspari; Nicoletta Banzola; Roberto Cevenini; Antonella Marangoni
Journal:  New Microbiol       Date:  2018-04-05       Impact factor: 2.479

Review 4.  Mycoplasma genitalium, an emerging sexually transmitted pathogen.

Authors:  C Cazanave; L E Manhart; C Bébéar
Journal:  Med Mal Infect       Date:  2012-09-10       Impact factor: 2.152

Review 5.  Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.

Authors:  Krishna Kannan; Alexander S Mankin
Journal:  Ann N Y Acad Sci       Date:  2011-12       Impact factor: 5.691

6.  Protocol for the detection of Mycoplasma genitalium by PCR from clinical specimens and subsequent detection of macrolide resistance-mediating mutations in region V of the 23S rRNA gene.

Authors:  Jørgen Skov Jensen
Journal:  Methods Mol Biol       Date:  2012

7.  Direct detection of macrolide resistance in Mycoplasma genitalium isolates from clinical specimens from France by use of real-time PCR and melting curve analysis.

Authors:  Arabella Touati; Olivia Peuchant; Jorgen S Jensen; Cécile Bébéar; Sabine Pereyre
Journal:  J Clin Microbiol       Date:  2014-02-26       Impact factor: 5.948

8.  Usefulness of a novel multiplex real-time PCR assay for the diagnosis of sexually-transmitted infections.

Authors:  Gema Fernández; Elisa Martró; Victoria González; Verónica Saludes; Elisabet Bascuñana; Clara Marcó; Belén Rivaya; Evelin López; Pep Coll; Lurdes Matas; Vicente Ausina
Journal:  Enferm Infecc Microbiol Clin       Date:  2015-12-22       Impact factor: 1.731

9.  Transmission and selection of macrolide resistant Mycoplasma genitalium infections detected by rapid high resolution melt analysis.

Authors:  Jimmy Twin; Jorgen S Jensen; Catriona S Bradshaw; Suzanne M Garland; Christopher K Fairley; Lim Yi Min; Sepehr N Tabrizi
Journal:  PLoS One       Date:  2012-04-20       Impact factor: 3.240

10.  Antimicrobial resistance in Mycoplasma genitalium sampled from the British general population.

Authors:  Rachel Pitt; Magnus Unemo; Pam Sonnenberg; Sarah Alexander; Simon Beddows; Michelle Jayne Cole; Soazig Clifton; Catherine H Mercer; Anne M Johnson; Catherine A Ison; Nigel Field
Journal:  Sex Transm Infect       Date:  2020-01-10       Impact factor: 3.519
  10 in total

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