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Literature DB >> 33077363

A Role for N6-Methyladenine in DNA Damage Repair.

Xing Zhang¹, Robert M Blumenthal², Xiaodong Cheng³.

Abstract

The leading cause of mutation due to oxidative damage is 8-oxo-2'-deoxyguanosine (8-oxoG) mispairing with adenine (Ade), which can occur in two ways. First, guanine of a G:C DNA base pair can be oxidized. If not repaired in time, DNA polymerases can mispair Ade with 8-oxoG in the template. This 8-oxoG:A can be repaired by enzymes that remove Ade opposite to template 8-oxoG, or 8-oxoG opposite to Cyt. Second, free 8-oxo-dGTP can be misincorporated by DNA polymerases into DNA opposite template Ade. However, there is no known repair activity that removes 8-oxoG opposite to template Ade. We suggest that a major role of N6-methyladenine in mammalian DNA is minimizing incorporation of 8-oxoG opposite to Ade by DNA polymerases following adduct formation.

Entities: Chemical Species

Keywords: 8-oxoguanine; DNA adenine methylation; MettL3-MettL14; YTHDC1; single-stranded DNA

Year: 2020 PMID： 33077363 PMCID： PMC7880869 DOI： 10.1016/j.tibs.2020.09.007

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

80 in total

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2. Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq.

Authors: Yun Ding; Aaron M Fleming; Cynthia J Burrows
Journal: J Am Chem Soc Date: 2017-02-13 Impact factor: 15.419

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Authors: María A Sánchez-Romero; Josep Casadesús
Journal: Nat Rev Microbiol Date: 2019-11-14 Impact factor: 60.633

4. Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells.

Authors: U Schibler; D E Kelley; R P Perry
Journal: J Mol Biol Date: 1977-10-05 Impact factor: 5.469

5. Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes.

Authors: T Malone; R M Blumenthal; X Cheng
Journal: J Mol Biol Date: 1995-11-03 Impact factor: 5.469

Review 6. Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness.

Authors: Indu Kapoor; Umesh Varshney
Journal: Curr Genet Date: 2020-04-05 Impact factor: 3.886

7. DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

Authors: Tao P Wu; Tao Wang; Matthew G Seetin; Yongquan Lai; Shijia Zhu; Kaixuan Lin; Yifei Liu; Stephanie D Byrum; Samuel G Mackintosh; Mei Zhong; Alan Tackett; Guilin Wang; Lawrence S Hon; Gang Fang; James A Swenberg; Andrew Z Xiao
Journal: Nature Date: 2016-03-30 Impact factor: 49.962

8. The m⁶A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.

Authors: Shaoru Wang; Yanyan Song; Yafen Wang; Xin Li; Boshi Fu; Yinong Liu; Jiaqi Wang; Lai Wei; Tian Tian; Xiang Zhou
Journal: Chem Sci Date: 2017-07-06 Impact factor: 9.825

9. N⁶-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.

Authors: Abdulkadir Abakir; Tom C Giles; Agnese Cristini; Jeremy M Foster; Nan Dai; Marta Starczak; Alejandro Rubio-Roldan; Miaomiao Li; Maria Eleftheriou; James Crutchley; Luke Flatt; Lorraine Young; Daniel J Gaffney; Chris Denning; Bjørn Dalhus; Richard D Emes; Daniel Gackowski; Ivan R Corrêa; Jose L Garcia-Perez; Arne Klungland; Natalia Gromak; Alexey Ruzov
Journal: Nat Genet Date: 2019-12-16 Impact factor: 38.330

10. N⁶-methyladenine in DNA antagonizes SATB1 in early development.

Authors: Zheng Li; Shuai Zhao; Raman V Nelakanti; Kaixuan Lin; Tao P Wu; Myles H Alderman; Cheng Guo; Pengcheng Wang; Min Zhang; Wang Min; Zongliang Jiang; Yinsheng Wang; Haitao Li; Andrew Z Xiao
Journal: Nature Date: 2020-07-15 Impact factor: 49.962

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1. Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA.

Authors: Dan Yu; Jujun Zhou; Qin Chen; Tao Wu; Robert M Blumenthal; Xing Zhang; Xiaodong Cheng
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2. Inhibition of Lipid Accumulation and Adipokine Levels in Maturing Adipocytes by Bauhinia rufescens (Lam.) Stem Bark Extract Loaded Titanium Oxide Nanoparticles.

Authors: Ghedeir M Alshammari; Abu ElGasim A Yagoub; Pandurangan Subash-Babu; Amro B Hassan; Doha M Al-Nouri; Mohammed A Mohammed; Mohammed A Yahya; Rasha Elsayim
Journal: Molecules Date: 2021-11-29 Impact factor: 4.411

A Role for N6-Methyladenine in DNA Damage Repair.

Review 1. Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.

2. Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq.

Review 3. The bacterial epigenome.

4. Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells.

5. Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes.

Review 6. Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness.

7. DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

8. The m⁶A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.

9. N⁶-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.

10. N⁶-methyladenine in DNA antagonizes SATB1 in early development.

1. Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA.

2. Inhibition of Lipid Accumulation and Adipokine Levels in Maturing Adipocytes by Bauhinia rufescens (Lam.) Stem Bark Extract Loaded Titanium Oxide Nanoparticles.

Review 3. The role of RNA m⁵C modification in cancer metastasis.

Review 4. The exploration of N6-deoxyadenosine methylation in mammalian genomes.

5. Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells.

Review 6. Novel methylation mark and essential hypertension.

7. Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.

Review 8. Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.

Review 1. Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.

Review 3. The bacterial epigenome.

Review 6. Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness.

Review 3. The role of RNA m5C modification in cancer metastasis.

Review 4. The exploration of N6-deoxyadenosine methylation in mammalian genomes.

Review 6. Novel methylation mark and essential hypertension.

Review 8. Functions, mechanisms, and therapeutic implications of METTL14 in human cancer.

Review 3. The role of RNA m⁵C modification in cancer metastasis.