Vinicius A do Rosario1, Courtney Chang2, Jaclyn Spencer3, Thilani Alahakone4, Steven Roodenrys5, Monique Francois6, Katrina Weston-Green7, Nadine Hölzel8, David S Nichols9, Katherine Kent10, David Williams11, Ian M R Wright12, Karen Charlton13. 1. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia. Electronic address: vadr998@uowmail.edu.au. 2. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia; Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia. Electronic address: cchang@uow.edu.au. 3. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia. Electronic address: jes647@uowmail.edu.au. 4. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia. Electronic address: tsa598@uowmail.edu.au. 5. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia. Electronic address: steven@uow.edu.au. 6. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia; Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia. Electronic address: francois@uow.edu.au. 7. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia; Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia; Molecular Horizons, University of Wollongong, NSW, 2522, Australia. Electronic address: kweston@uow.edu.au. 8. Tasmanian Institute of Agriculture, University of Tasmania, Hobart, 7000, Australia. Electronic address: nadine.macha@utas.edu.au. 9. Central Sciences Laboratory, University of Tasmania, Hobart, TAS, 7000, Australia. Electronic address: d.nichols@utas.edu.au. 10. Centre for Rural Health, University of Tasmania, Launceston, TAS, 7250, Australia. Electronic address: katherine.kent@utas.edu.au. 11. Department of Agriculture and Fisheries, QLD, 4108, Australia. Electronic address: david.williams@daf.qld.gov.au. 12. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia; Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia; College of Medicine and Dentistry, James Cook University, Cairns, QLD, 4870, Australia. Electronic address: ian.wright@jcu.edu.au. 13. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia; Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia. Electronic address: karenc@uow.edu.au.
Abstract
BACKGROUND & AIMS:Postprandial metabolic imbalances are important indicators of later developing cardiovascular disease (CVD). This study investigated the effects of food anthocyanins on vascular and microvascular function, and CVD associated biomarkers following a high fat high energy (HFHE) meal challenge in overweight older adults. METHODS:Sixteen subjects (13 female, 3 male, mean age 65.9 SD 6.0 and body mass index 30.6 kg/m2 SD 3.9) participated in a crossover, randomized, controlled, double-blind clinical trial (registered under Australian New Zealand Clinical Trials Registry, identifier no. ACTRN12620000437965). Participants consumed a HFHE meal with a 250 mL dose of either intervention (anthocyanins-rich Queen Garnet Plum) or control (apricot) juice. Blood samples and blood pressure measures were collected at baseline, 2 h and 4 h following the HFHE meal. Vascular and microvascular function were evaluated at baseline and 2 h after the HFHE meal. RESULTS: Participants had a higher 2 h postprandial flow-mediated dilatation (+1.14%) and a higher microvascular post-occlusive reactive hyperaemia (+0.10 perfusion units per mmHg) when allocated to the anthocyanin compared to the control arm (P = 0.019 and P = 0.049, respectively). C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). No significant postprandial differences were observed between treatments for blood pressure, triacylglycerol, total cholesterol, serum derivatives of reactive oxidative metabolites, tumor necrosis factor alpha, interleukin-1 beta, or maximum microvascular perfusion following iontophoresis of acetylcholine. CONCLUSION:Fruit-based anthocyanins attenuated the potential postprandial detrimental effects of a HFHE challenge on parameters of vascular and microvascular function, and inflammatory biomarkers in overweight older adults. Anthocyanins may reduce cardiovascular risk associated with endothelial dysfunction and inflammatory responses to a typical high fat 'Western' meal. Further studies are required to better elucidate the clinical implications of postprandial biomarkers of CVD.
RCT Entities:
BACKGROUND & AIMS: Postprandial metabolic imbalances are important indicators of later developing cardiovascular disease (CVD). This study investigated the effects of food anthocyanins on vascular and microvascular function, and CVD associated biomarkers following a high fat high energy (HFHE) meal challenge in overweight older adults. METHODS: Sixteen subjects (13 female, 3 male, mean age 65.9 SD 6.0 and body mass index 30.6 kg/m2 SD 3.9) participated in a crossover, randomized, controlled, double-blind clinical trial (registered under Australian New Zealand Clinical Trials Registry, identifier no. ACTRN12620000437965). Participants consumed a HFHE meal with a 250 mL dose of either intervention (anthocyanins-rich Queen Garnet Plum) or control (apricot) juice. Blood samples and blood pressure measures were collected at baseline, 2 h and 4 h following the HFHE meal. Vascular and microvascular function were evaluated at baseline and 2 h after the HFHE meal. RESULTS:Participants had a higher 2 h postprandial flow-mediated dilatation (+1.14%) and a higher microvascular post-occlusive reactive hyperaemia (+0.10 perfusion units per mmHg) when allocated to the anthocyanin compared to the control arm (P = 0.019 and P = 0.049, respectively). C-reactive protein was lower 4 h postprandially in the anthocyanins (1.80 mg/L, IQR 0.90) vs control arm (2.30 mg/L, IQR 1.95) (P = 0.026), accompanied by a trend for lower concentrations of interleukin-6 (P = 0.075). No significant postprandial differences were observed between treatments for blood pressure, triacylglycerol, total cholesterol, serum derivatives of reactive oxidative metabolites, tumor necrosis factor alpha, interleukin-1 beta, or maximum microvascular perfusion following iontophoresis of acetylcholine. CONCLUSION: Fruit-based anthocyanins attenuated the potential postprandial detrimental effects of a HFHE challenge on parameters of vascular and microvascular function, and inflammatory biomarkers in overweight older adults. Anthocyanins may reduce cardiovascular risk associated with endothelial dysfunction and inflammatory responses to a typical high fat 'Western' meal. Further studies are required to better elucidate the clinical implications of postprandial biomarkers of CVD.
Authors: Peter J Curtis; Lindsey Berends; Vera van der Velpen; Amy Jennings; Laura Haag; Preeti Chandra; Colin D Kay; Eric B Rimm; Aedín Cassidy Journal: Clin Nutr Date: 2021-11-27 Impact factor: 7.324
Authors: Muhammad Faisal Manzoor; Abid Hussain; Nenad Naumovski; Muhammad Modassar Ali Nawaz Ranjha; Nazir Ahmad; Emad Karrar; Bin Xu; Salam A Ibrahim Journal: Front Nutr Date: 2022-07-19