Dhruv S Gaur1, Brendan P Jacka1, Traci C Green2, Elizabeth A Samuels3, Scott E Hadland4, Maxwell S Krieger1, Jesse L Yedinak1, Brandon D L Marshall5. 1. Department of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA. 2. Department of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA; Department of Emergency Medicine, The Warren Alpert Medical School, Brown University. 55 Claverick Street, Suite 100, Providence, RI 02903, USA; Department of Emergency Medicine, Boston University School of Medicine. 771 Albany St, Room 1208, Boston, MA 02118, USA; Rhode Island Hospital, COBRE on Opioids and Overdose. 8 Third Street, 2nd Floor, Providence, RI 02906, USA. 3. Department of Emergency Medicine, The Warren Alpert Medical School, Brown University. 55 Claverick Street, Suite 100, Providence, RI 02903, USA. 4. Grayken Center for Addiction and Department of Pediatrics, Boston Medical Center. One Boston Medical Center Place, Boston, MA 02118, USA; Department of Pediatrics, Division of General Pediatrics, Boston University School of Medicine. 88 East Newton Street, Vose Hall Room 322, Boston, MA, USA, 02118. 5. Department of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA. Electronic address: brandon_marshall@brown.edu.
Abstract
PURPOSE: Drug overdose mortality remains a public health concern in many countries globally. In the US, overdoses involving synthetic opioids are the primary contributor to overdose mortality. We aimed to assess trends in overdose death due to synthetic opioids among young people and describe key demographic and temporal changes. METHODS: Data from the US National Vital Statistics System Multiple Cause of Death files for 2009-2018 were analysed to determine age-specific overdose death rates by region (i.e. east versus west of the Mississippi River). Age-adjusted overdose mortality rates were used to compare demographic differences in all drug and synthetic opioid overdose among young people (aged 15-34 years) using a joinpoint regression with Poisson-approximated standard errors. RESULTS: Driven by synthetic opioid overdose, the age burden of mortality shifted towards young people in eastern states and remained approximately constant in western states over the study period. The highest increases in drug overdose mortality rates were observed in young Black and Hispanic people and those living in large metropolitan areas. CONCLUSIONS: Rapid changes in the demographics of overdose demonstrate distinct but overlapping US overdose sub-epidemics, and highlight the need for targeted interventions to reduce overdose risk in young people.
PURPOSE:Drug overdosemortality remains a public health concern in many countries globally. In the US, overdoses involving synthetic opioids are the primary contributor to overdosemortality. We aimed to assess trends in overdose death due to synthetic opioids among young people and describe key demographic and temporal changes. METHODS: Data from the US National Vital Statistics System Multiple Cause of Death files for 2009-2018 were analysed to determine age-specific overdose death rates by region (i.e. east versus west of the Mississippi River). Age-adjusted overdosemortality rates were used to compare demographic differences in all drug and synthetic opioid overdose among young people (aged 15-34 years) using a joinpoint regression with Poisson-approximated standard errors. RESULTS: Driven by synthetic opioid overdose, the age burden of mortality shifted towards young people in eastern states and remained approximately constant in western states over the study period. The highest increases in drug overdosemortality rates were observed in young Black and Hispanic people and those living in large metropolitan areas. CONCLUSIONS: Rapid changes in the demographics of overdose demonstrate distinct but overlapping US overdose sub-epidemics, and highlight the need for targeted interventions to reduce overdose risk in young people.
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