Yonghwan Kim1, Hyeong-Seop Kim2, Jae-Woo Lee1, Ye-Seul Kim1, Hyo-Sun You1, Yoon-Jong Bae2, Hyeong-Cheol Lee1, Ye-Eun Han2, Eun-A Choi2, Joungyoun Kim3, Hee-Taik Kang4. 1. Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Chungbuk, Republic of Korea. 2. Department of Information & Statistics, Chungbuk National University, Chungbuk, Cheongju, Republic of Korea. 3. Department of Information & Statistics, Chungbuk National University, Chungbuk, Cheongju, Republic of Korea. Electronic address: joungyoun@chungbuk.ac.kr. 4. Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Chungbuk, Republic of Korea; Department of Family Medicine, Chungbuk National University College of Medicine, Cheongju, Chungbuk, Republic of Korea. Electronic address: kanght0818@gmail.com.
Abstract
AIMS: The aim of this study is to investigate the association between metformin usage and dementia in an elderly Korean population. METHODS: Participants were divided into five groups: metformin non-users with diabetes mellitus (DM), metformin users with DM (low-, mid-, and high-users), and non-diabetic Individuals. Dementia was defined with primary diagnostic dementia codes according to the 10th edition of the International Classification of Diseases. To compare the incidence rate of dementia among the five groups, Kaplan-Meier estimates and log-rank test were employed. Also, to control the confounding factors, Cox proportional hazards regression models were fitted in a sequential adjustment. RESULTS: The median follow-up was 12.4 years. The overall incidence rate of dementia was 11.3% (8.4% in men and 13.9% in women). Compared with metformin non-users, hazard ratios (95% confidence intervals) of low-, mid-, and high-users and non-diabetic individuals for dementia were 0.97 (0.73-1.28), 0.77 (0.58-1.01), 0.48 (0.35-0.67), and 0.98 (0.84-1.15), respectively, in men, respectively, and 0.90 (0.65-0.98), 0.61 (0.50-0.76), 0.46 (0.36-0.58), and 0.92 (0.81-1.04), respectively, in women, after full adjustment of confounding variables. CONCLUSIONS: Metformin use in an elderly population with DM reduced dementia risk in a dose-response manner.
AIMS: The aim of this study is to investigate the association between metformin usage and dementia in an elderly Korean population. METHODS:Participants were divided into five groups: metformin non-users with diabetes mellitus (DM), metformin users with DM (low-, mid-, and high-users), and non-diabetic Individuals. Dementia was defined with primary diagnostic dementia codes according to the 10th edition of the International Classification of Diseases. To compare the incidence rate of dementia among the five groups, Kaplan-Meier estimates and log-rank test were employed. Also, to control the confounding factors, Cox proportional hazards regression models were fitted in a sequential adjustment. RESULTS: The median follow-up was 12.4 years. The overall incidence rate of dementia was 11.3% (8.4% in men and 13.9% in women). Compared with metformin non-users, hazard ratios (95% confidence intervals) of low-, mid-, and high-users and non-diabetic individuals for dementia were 0.97 (0.73-1.28), 0.77 (0.58-1.01), 0.48 (0.35-0.67), and 0.98 (0.84-1.15), respectively, in men, respectively, and 0.90 (0.65-0.98), 0.61 (0.50-0.76), 0.46 (0.36-0.58), and 0.92 (0.81-1.04), respectively, in women, after full adjustment of confounding variables. CONCLUSIONS:Metformin use in an elderly population with DM reduced dementia risk in a dose-response manner.
Authors: Jiahui Dai; Kayleen Deanna Ports; Maria M Corrada; Andrew O Odegaard; Joan O'Connell; Luohua Jiang Journal: J Alzheimers Dis Rep Date: 2022-08-03