Literature DB >> 33068538

Water Loss in Aging Erythrocytes Provides a Clue to a General Mechanism of Cellular Senescence.

Allen P Minton1.   

Abstract

Experimental evidence for age-dependent loss of intracellular water content as a widespread concomitant of cellular senescence is reviewed. Quantitative models are presented, indicating that an age-dependent increase in macromolecular crowding resulting from water loss may be responsible for three observed phenomena: a general age-dependent loss of intracellular protein solubility, a delayed and rapid appearance of high molecular weight aggregates, and an age-dependent transfer of intracellular protein from dilute to concentrated or condensed phases. Published by Elsevier Inc.

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Year:  2020        PMID： 33068538      PMCID： PMC7732744          DOI： 10.1016/j.bpj.2020.10.004

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  49 in total

Review 1.  Crowding and the polymerization of sickle hemoglobin.

Authors:  Frank A Ferrone; Maria A Rotter
Journal:  J Mol Recognit       Date:  2004 Sep-Oct       Impact factor: 2.137

Review 2.  Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences.

Authors:  Huan-Xiang Zhou; Germán Rivas; Allen P Minton
Journal:  Annu Rev Biophys       Date:  2008       Impact factor: 12.981

Review 3.  Protein aggregation as a paradigm of aging.

Authors:  Ariel B Lindner; Alice Demarez
Journal:  Biochim Biophys Acta       Date:  2009-06-13

4.  Analysis of non-ideal behavior in concentrated hemoglobin solutions.

Authors:  P D Ross; A P Minton
Journal:  J Mol Biol       Date:  1977-05-25       Impact factor: 5.469

5.  The effect of non-aggregating proteins upon the gelation of sickle cell hemoglobin: model calculations and data analysis.

Authors:  P D Ross; A P Minton
Journal:  Biochem Biophys Res Commun       Date:  1979-06-27       Impact factor: 3.575

6.  Self-association in highly concentrated solutions of myoglobin: a novel analysis of sedimentation equilibrium of highly nonideal solutions.

Authors:  A P Minton; M S Lewis
Journal:  Biophys Chem       Date:  1981-12       Impact factor: 2.352

7.  Chemical potential measurements of deoxyhemoglobin S polymerization. Determination of the phase diagram of an assembling protein.

Authors:  M S Prouty; A N Schechter; V A Parsegian
Journal:  J Mol Biol       Date:  1985-08-05       Impact factor: 5.469

8.  Age-related changes in rat interstitial matrix hydration and serum proteins.

Authors:  B J Barber; R A Babbitt; S Parameswaran; S Dutta
Journal:  J Gerontol A Biol Sci Med Sci       Date:  1995-09       Impact factor: 6.053

9.  Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation.

Authors:  Nicole Groh; Anika Bühler; Chaolie Huang; Ka Wan Li; Pim van Nierop; August B Smit; Marcus Fändrich; Frank Baumann; Della C David
Journal:  Front Aging Neurosci       Date:  2017-05-17       Impact factor: 5.750

10.  Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.

Authors:  Sara Wagner-Valladolid; Amberley D Stephens; Chaolie Huang; Raimund Jung; Chetan Poudel; Tessa Sinnige; Marie C Lechler; Nicole Schlörit; Meng Lu; Romain F Laine; Claire H Michel; Michele Vendruscolo; Clemens F Kaminski; Gabriele S Kaminski Schierle; Della C David
Journal:  Elife       Date:  2019-05-03       Impact factor: 8.140
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  2 in total

1.  Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells.

Authors:  Alla Shatrova; Elena Burova; Natalja Pugovkina; Alisa Domnina; Nikolaj Nikolsky; Irina Marakhova
Journal:  Sci Rep       Date:  2022-07-01       Impact factor: 4.996

2.  Stability of Intracellular Protein Concentration under Extreme Osmotic Challenge.

Authors:  Jordan E Hollembeak; Michael A Model
Journal:  Cells       Date:  2021-12-14       Impact factor: 6.600
  2 in total

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