Literature DB >> 33067662

CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease.

Qicai Liu1, Yunfeng Lin2, Sheng Zhang3,4, Min Chen5, Qingquan Chen5, Hongbin Rui6, Fang Wang7, Xiaoting Lv8, Feng Gao9,10.   

Abstract

Similar to other immune-mediated diseases, IgG4-related disease (IgG4-RD) is the disease that develops in genetically susceptible individuals exposed to external or endogenous antigens. In the present study, it was confirmed that MAG (myelin-associated glycoprotein) antibodies (IgG, IgG4, and IgM) were detected by immunofluorescence (IFA) in serum of the patients with IgG4-RD. In vivo, the levels of prolactin and Th2 cytokines in CGRP+/- rats were higher than those in wild-type. Our findings indicate that the presence of CGRP-deficiency-mediated MAG antibodies is a probable molecular basis for the initial events which were triggered in IgG4-RD immune responses via prolactin upregulation.

Entities:  

Keywords:  CGRP; IgG4-RD; MAG antibody; prolactin

Year:  2020        PMID： 33067662     DOI： 10.1007/s10753-020-01350-6

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  2 in total

Review 1.  Myelin-associated glycoprotein (MAG): past, present and beyond.

Authors:  Richard H Quarles
Journal:  J Neurochem       Date:  2007-01-04       Impact factor: 5.372

2.  Stimulation of sensory nerves and CGRP attenuate pancreatic damage in ischemia/reperfusion induced pancreatitis.

Authors:  Artur Dembiński; Zygmunt Warzecha; Piotr Ceranowicz; Jolanta Jaworek; Ryszard Sendur; Anna Knafel; Marcin Dembiński; Jan Bilski; Wiesław W Pawlik; Romana Tomaszewska; Jerzy Stachura; Stanisław J Konturek
Journal:  Med Sci Monit       Date:  2003-12
  2 in total
  3 in total

1.  Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway.

Authors:  Feng Lv; Longbiao Yang; Jianxiu Wang; Zhixiang Chen; Qizhao Sun; Peiguo Zhang; Chentong Guan; Yanbin Liu
Journal:  Neurochem Res       Date:  2021-03-13       Impact factor: 3.996

2.  DNA Methylation Pattern of CALCA and CALCB in Extremely Premature Infants with Monochorionic Triplets after Single-Embryo Transfer.

Authors:  Feng Gao; Yujia Guo; Xingting Chen; Qiuyang Gu; Shirong Huang; Qingquan Chen; Xiaoming Xu; Kai Zeng; Huilin Zhou; Yilu Zou; Qicai Liu
Journal:  Oxid Med Cell Longev       Date:  2021-10-05       Impact factor: 6.543

Review 3.  The crucial role of prolactin-lactogenic hormone in Covid-19.

Authors:  Hayder M Al-Kuraishy; Ali I Al-Gareeb; Monica Butnariu; Gaber El-Saber Batiha
Journal:  Mol Cell Biochem       Date:  2022-02-11       Impact factor: 3.842
  3 in total

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