Justin D Russell1, Monica A Marsee2, Carl F Weems3. 1. Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: jdrussell3@wisc.edu. 2. Department of Psychology, Iowa State University, Ames, Iowa. 3. Department of Human Development and Family Studies, Iowa State University, Ames, Iowa. Electronic address: cweems@iastate.edu.
Abstract
BACKGROUND: There is evidence that the amygdala undergoes extensive development. The exact nature of this change remains less clear, with evidence suggesting linear, curvilinear, and null effects. The aim of this study was the identification of a normative reference of left and right amygdala development by parceling variance into separate effects of age and longitudinal growth. METHODS: Data came from the National Institutes of Health MRI Study of Normal Brain Development. Participants in this sample were 54% female and ranged in age from 5 to 18 years (mean = 11.37 years) at study entry. RESULTS: As predicted, the age at initial scan moderated the slope of both left and right amygdala volumes, demonstrating that the nature of longitudinal growth varies across age (i.e., steeper slopes observed among those first scanned at an early age). Follow-up analysis showed that the positive longitudinal growth slope becomes nonsignificant at 13.1 years of age for the left amygdala and at 14.5 years for the right amygdala, suggesting that growth of the left amygdala peaks earlier than growth of the right amygdala. CONCLUSIONS: Findings suggest that rapid increases in volumes at early ages decline as youths enter adolescence and may turn to minor declines in volume during late adolescence or early adulthood.
BACKGROUND: There is evidence that the amygdala undergoes extensive development. The exact nature of this change remains less clear, with evidence suggesting linear, curvilinear, and null effects. The aim of this study was the identification of a normative reference of left and right amygdala development by parceling variance into separate effects of age and longitudinal growth. METHODS: Data came from the National Institutes of Health MRI Study of Normal Brain Development. Participants in this sample were 54% female and ranged in age from 5 to 18 years (mean = 11.37 years) at study entry. RESULTS: As predicted, the age at initial scan moderated the slope of both left and right amygdala volumes, demonstrating that the nature of longitudinal growth varies across age (i.e., steeper slopes observed among those first scanned at an early age). Follow-up analysis showed that the positive longitudinal growth slope becomes nonsignificant at 13.1 years of age for the left amygdala and at 14.5 years for the right amygdala, suggesting that growth of the left amygdala peaks earlier than growth of the right amygdala. CONCLUSIONS: Findings suggest that rapid increases in volumes at early ages decline as youths enter adolescence and may turn to minor declines in volume during late adolescence or early adulthood.
Authors: J N Giedd; A C Vaituzis; S D Hamburger; N Lange; J C Rajapakse; D Kaysen; Y C Vauss; J L Rapoport Journal: J Comp Neurol Date: 1996-03-04 Impact factor: 3.215
Authors: Nicholas L Balderston; Douglas H Schultz; Lauren Hopkins; Fred J Helmstetter Journal: Soc Cogn Affect Neurosci Date: 2015-05-11 Impact factor: 3.436
Authors: Matthew D Albaugh; Tuong-Vi Nguyen; Simon Ducharme; D Louis Collins; Kelly N Botteron; Nicholas D'Alberto; Alan C Evans; Sherif Karama; James J Hudziak Journal: Biol Psychol Date: 2017-02-07 Impact factor: 3.251
Authors: Nim Tottenham; Todd A Hare; Brian T Quinn; Thomas W McCarry; Marcella Nurse; Tara Gilhooly; Alexander Millner; Adriana Galvan; Matthew C Davidson; Inge-Marie Eigsti; Kathleen M Thomas; Peter J Freed; Elizabeth S Booma; Megan R Gunnar; Margaret Altemus; Jane Aronson; B J Casey Journal: Dev Sci Date: 2010-01-01
Authors: Anne-Lise Goddings; Kathryn L Mills; Liv S Clasen; Jay N Giedd; Russell M Viner; Sarah-Jayne Blakemore Journal: Neuroimage Date: 2013-10-11 Impact factor: 6.556